Jokinen E J, Alfthan O S, Oravisto K J
Clin Exp Immunol. 1972 Jul;11(3):333-9.
Sera from thirty-three female patients with interstitial cystitis were studied for the presence of antitissue antibodies and a positive result was obtained in thirty-one cases (94%). Antinuclear antibodies detected by the immunofluorescence method were found in 85% of the sera in titres of 1:10 or higher. However, the LE-cell phenomenon was not seen in a single patient. complement-fixing antibodies to crude kidney homogenate occurred in 48% of the sera. Antibodies, with an incidence not exceeding that expected in control groups, were against smooth muscle, thyroglobulin and gastric parietal cells. None of the patients had mitochondrial or thyroid cytoplasmic antibodies, rheumatoid factors or biologic false-positive reactions for syphilis. Bladder specific antibodies could not be demonstrated by the double layer immunofluorescence method. The results indicate that interstitial cystitis belongs to that group of autoimmune diseases in which the disease is restricted to one organ, whereas the autoantibodies are non-organ specific.
对33例间质性膀胱炎女性患者的血清进行了抗组织抗体检测，31例（94%）结果呈阳性。通过免疫荧光法检测，85%的血清中发现了滴度为1:10或更高的抗核抗体。然而，未在任何一例患者中观察到LE细胞现象。48%的血清中出现了针对肾脏粗提物的补体结合抗体。针对平滑肌、甲状腺球蛋白和胃壁细胞的抗体发生率不超过对照组预期水平。所有患者均无线粒体或甲状腺胞浆抗体、类风湿因子或梅毒生物学假阳性反应。双层免疫荧光法未能证实膀胱特异性抗体。结果表明，间质性膀胱炎属于自身免疫性疾病组，其中疾病局限于一个器官，而自身抗体是非器官特异性的。
