Hailesilassie Natnael Yikeber, Geneti Soressa Abebe, Agonafir Balkew
College of Health Sciences, School of Medicine, Department of Anatomy, Dilla University, Dilla, Ethiopia.
College of Health Sciences, School of Medicine, Department of Anatomy, Addis Ababa University, Addis Ababa, Ethiopia.
BMC Gastroenterol. 2025 Oct 28;25(1):767. doi: 10.1186/s12876-025-04252-9.
The gallstone disease is gradually becoming a burden of healthcare systems throughout world. The frequency of gallstone disease in Ethiopia has been the subject of few investigations and to the best of our knowledge, limited evidence of published research has examined the risk factors linked with gallstone disease. The main objective of the current study was to assess the prevalence of gallstone disease and associated factors among patients who visited the surgical department of Debre Birhan Comprehensive Specialization Hospital.
This retrospective institution-based cross-sectional study was conducted at Debre Birhan Comprehensive Specialized Hospital's Surgical Department. A total of 169 patients, aged 18 and above years, were selected between January 2020 and December 2022 using a simple random sampling method. The collected data were analyzed by using SPSS version 25. Descriptive statistics were done, and binary and multiple logistic regression analyses were performed. Risk variables were found using multivariable logistic regression.
The study included 165 participants, 86 (52.1%) males and 79 (47.9%) females. The mean age of the participants was 41.58 ± 16.185 years. The overall prevalence of gallstone disease was 7.9%, with a greater prevalence observed in women (15.2%) than in men (1.2%). The prevalence of gallstone disease was found to be highest (61.3%) among participants aged between 26 and 45 years, with a Decrease in prevalence after the age of 65 years. Multiple logistic regression analysis revealed that female sex (OR = 6.88), alcohol intake for more than five years (OR = 4.27), and history of gastrointestinal surgery (OR = 6.5) were significantly associated with gallstone disease. Further subgroup multiple logistic regression analysis in females revealed that parity (OR = 8.5) and, after adjusting for alcohol intake, diabetes (OR = 4.6) and hypertension (OR = 1.37) were significantly associated with gallstone disease.
In conclusion, the prevalence of gallstone disease was 7.9%, and the disease was fairly common in our study area. Female sex, alcohol intake for more than five years, and a history of gastrointestinal surgery were strongly associated with the occurrence of gallstone disease.
胆结石疾病正逐渐成为全球医疗保健系统的负担。埃塞俄比亚胆结石疾病的发病率鲜有研究，据我们所知，已发表研究中关于与胆结石疾病相关危险因素的证据有限。本研究的主要目的是评估德布雷比尔汉综合专科医院外科就诊患者中胆结石疾病的患病率及相关因素。
本项基于机构的回顾性横断面研究在德布雷比尔汉综合专科医院外科开展。2020年1月至2022年12月期间，采用简单随机抽样方法选取了169例年龄在18岁及以上的患者。收集的数据使用SPSS 25版本进行分析。进行描述性统计，并进行二元和多元逻辑回归分析。使用多变量逻辑回归确定风险变量。
该研究纳入了165名参与者，其中男性86名（52.1%），女性79名（47.9%）。参与者的平均年龄为41.58±16.185岁。胆结石疾病的总体患病率为7.9%，女性患病率（15.2%）高于男性（1.2%）。胆结石疾病的患病率在26至45岁的参与者中最高（61.3%），65岁以后患病率下降。多元逻辑回归分析显示，女性（比值比=6.88）、饮酒超过五年（比值比=4.27）和胃肠道手术史（比值比=6.5）与胆结石疾病显著相关。对女性进行的进一步亚组多元逻辑回归分析显示，产次（比值比=8.5）以及在调整饮酒因素后，糖尿病（比值比=4.6）和高血压（比值比=1.37）与胆结石疾病显著相关。
总之，胆结石疾病的患病率为7.9%，在我们的研究区域该疾病相当常见。女性、饮酒超过五年和胃肠道手术史与胆结石疾病的发生密切相关。
