Aytaş Çağla, Cauduro Alberto, Falzone Cristian, Gianni Stefania, Tomba Anna, Cantile Carlo
Dipartimento di Scienze Veterinarie, University of Pisa, Viale delle Piagge n. 2, 56124 Pisa, Italy.
Clinica Veterinaria Neurovet, Via Maestri del Lavoro n. 29, 20025 Legnano, Italy.
Animals (Basel). 2025 Oct 16;15(20):3010. doi: 10.3390/ani15203010.
Human hemangioblastoma is a benign, slow-growing, highly vascular neoplasm. The tumor most commonly arises in the cerebral hemispheres and cerebellum, where it is more frequently observed in patients with von Hippel-Lindau disease. In veterinary medicine, hemangioblastoma has only been described in the central nervous system of dogs and in the skin of lambs. Our study aimed to characterize the clinical and neuropathological features of five cases of canine spinal cord hemangioblastoma and one case of sciatic nerve localization, and to compare these results with those reported in the veterinary literature. Diagnoses were achieved by neurological examination, neuroimaging, surgery or post-mortem examination, histopathology, and immunohistochemistry. All tumors were composed of numerous, haphazardly arranged capillaries lined by plump endothelium and interstitial fusiform to stellate stromal cells. Immunohistochemically, the stromal cells were strongly immunolabeled with NSE and carbonic anhydrase IX and were negative for von Willebrand factor VIII and inhibin-α. Canine hemangioblastoma exhibits morphological and immunohistochemical features comparable to the human counterpart, although the latter is mostly positive for inhibin-α. Surgery may be effective in cases of intradural-extramedullary and peripheral nerve locations, as in humans. This is the first report of peripheral nerve hemangioblastoma in animals.
人类血管母细胞瘤是一种良性、生长缓慢、血管丰富的肿瘤。该肿瘤最常见于大脑半球和小脑，在冯·希佩尔-林道病患者中更常观察到。在兽医学中，血管母细胞瘤仅在犬的中枢神经系统和羔羊的皮肤中被描述过。我们的研究旨在描述5例犬脊髓血管母细胞瘤和1例坐骨神经定位病例的临床和神经病理学特征，并将这些结果与兽医文献中报道的结果进行比较。通过神经学检查、神经影像学、手术或尸检、组织病理学和免疫组织化学进行诊断。所有肿瘤均由大量排列杂乱的毛细血管组成，内衬丰满的内皮细胞和间质梭形至星状基质细胞。免疫组织化学方面，基质细胞被神经元特异性烯醇化酶（NSE）和碳酸酐酶IX强烈免疫标记，而血管性血友病因子VIII和抑制素-α呈阴性。犬血管母细胞瘤表现出与人类相似的形态学和免疫组织化学特征，尽管人类血管母细胞瘤大多对抑制素-α呈阳性。与人类一样，手术对于硬膜内髓外和周围神经部位的病例可能有效。这是动物周围神经血管母细胞瘤的首次报道。
