牛磺酸在大鼠体内的摄取研究及其对实验性局灶性癫痫病程的影响。

Uptake studies of taurine in vivo and its effects on the course of experimental focal epilepsy in rats.

作者信息

Wheler G H, Osborne R H, Bradford H F, Davison A N

出版信息

Brain Res. 1977 Nov 18;136(3):535-42. doi: 10.1016/0006-8993(77)90077-4.

Abstract

The passage of orally administered taurine across the intestinal wall to the blood plasma and target sites of neuromuscular excitability has been studied. This has been correlated with the effect of repeated oral dosing on the manifestations of cobalt-induced epilepsy in the rat. The blood-brain barrier and the organ distribution of taurine uptake have important implications in testing its effect on hyperexcitability phenomena.

摘要

已经对口服牛磺酸穿过肠壁进入血浆以及神经肌肉兴奋性靶位点的过程进行了研究。这与重复口服给药对大鼠钴诱导癫痫表现的影响相关。血脑屏障以及牛磺酸摄取的器官分布对于测试其对过度兴奋现象的作用具有重要意义。