Xu Ziyi, Meng Rong, Wang Yue, Sun Yuxuan, Qiao Jiao, Yao Yang, Peng Qiang
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Bioengineering (Basel). 2025 Sep 25;12(10):1021. doi: 10.3390/bioengineering12101021.
Two-dimensional (2D) nanomaterials have attracted growing attention in the field of oral medicine due to their unique physicochemical properties, including high surface area, adjustable surface chemistry, and exceptional biocompatibility. In recent years, a variety of 2D materials, including graphene-based nanomaterials, black phosphorus nanosheets, MXenes, layered double hydroxides (LDHs), transition metal dichalcogenides (TMDs), 2D metal-organic frameworks (MOFs), and polymer-based nanosheets, have been extensively explored for the treatment of oral diseases. These functional materials demonstrate multiple therapeutic capabilities, such as antibacterial activity, reactive oxygen species (ROS) scavenging, anti-inflammatory modulation, and promotion of tissue regeneration. In this review, we systematically summarize the recent advances of 2D nanomaterials in the treatment of common oral diseases such as dental caries, periodontitis, oral cancer and peri-implantitis. The underlying therapeutic mechanisms are also summarized. Challenges for clinical translation of these nanomaterials and the possible solutions are discussed as well.
二维（2D）纳米材料因其独特的物理化学性质，包括高比表面积、可调节的表面化学性质和优异的生物相容性，在口腔医学领域受到越来越多的关注。近年来，包括基于石墨烯的纳米材料、黑磷纳米片、MXenes、层状双氢氧化物（LDHs）、过渡金属二硫属化物（TMDs）、二维金属有机框架（MOFs）和基于聚合物的纳米片在内的多种二维材料已被广泛探索用于口腔疾病的治疗。这些功能材料展示出多种治疗能力，如抗菌活性、活性氧（ROS）清除、抗炎调节和促进组织再生。在这篇综述中，我们系统地总结了二维纳米材料在治疗龋齿、牙周炎、口腔癌和种植体周围炎等常见口腔疾病方面的最新进展。还总结了潜在的治疗机制。此外，还讨论了这些纳米材料临床转化面临的挑战以及可能的解决方案。
