Loth Francis, Fischer Paul F, Bassiouny Hisham S
Departments of Mechanical and Industrial Engineering and Bioengineering, University of Illinois at Chicago, Chicago, Illinois 60607.
Mathematics and Computer Science Division, Argonne National Laboratory, Argonne, Illinois 60439.
Annu Rev Fluid Mech. 2008 Jan;40:367-393. doi: 10.1146/annurev.fluid.40.111406.102119.
Blood flow in end-to-side autogenous or prosthetic graft anastomoses is of great interest to biomedical researchers because the biomechanical force profile engendered by blood flow disturbances at such geometric transitions is thought to play a significant role in vascular remodeling and graft failure. Thus, investigators have extensively studied anastomotic blood flow patterns in relation to graft failure with the objective of enabling the design of a more optimal graft anastomotic geometry. In contrast to arterial bifurcations, surgically created anastomoses can be modified to yield a flow environment that improves graft longevity. Understanding blood flow patterns at anastomotic junctions is a challenging problem because of the highly varying and complex three-dimensional nature of the geometry that is subjected to pulsatile and, occasionally, turbulent flow.
端端自体或人工血管吻合术中的血流情况备受生物医学研究人员关注，因为在这种几何形状转变处，血流紊乱产生的生物力学力分布被认为在血管重塑和移植物失败中起着重要作用。因此，研究人员广泛研究了与移植物失败相关的吻合口血流模式，目的是设计出更优化的移植物吻合几何形状。与动脉分叉不同，手术创建的吻合口可以进行修改，以产生改善移植物寿命的血流环境。由于吻合口处的几何形状具有高度变化且复杂的三维特性，且受到脉动流以及偶尔的湍流影响，了解吻合口处的血流模式是一个具有挑战性的问题。
