Chan V, Besser G M, Landon J
Br Med J. 1972 Dec 23;4(5842):699-701. doi: 10.1136/bmj.4.5842.699.
The day to day variation and the effects of oestrogen on the urinary excretion of thyroxine (T-4) were studied in euthyroid women and men. Serial urinary T-4 values over a period of 28 consecutive days were found to lie within relatively narrow limits except for a transient increase during menstruation in women. During oestrogen therapy urinary T-4 was unchanged, but an appreciable rise was seen after stopping oral ovulation inhibitors in women. A similar effect was seen in men after three days' treatment with 20 mug/day of ethinyloestradiol. The increased urinary T-4 excretion on oestrogen withdrawal reached a maximum in one to three days. This response contrasted with that produced by phenytoin, a drug known to bind to thyroxine binding globulin, and which resulted in increased urinary T-4 excretion during the period that it was being administered.
对甲状腺功能正常的女性和男性，研究了雌激素对甲状腺素（T-4）尿排泄的每日变化及影响。连续28天的系列尿T-4值除女性月经期间有短暂升高外，均处于相对较窄的范围内。雌激素治疗期间尿T-4无变化，但女性停用口服排卵抑制剂后尿T-4明显升高。男性每天服用20μg乙炔雌二醇治疗三天后也出现类似效果。雌激素撤药后尿T-4排泄增加在1至3天达到最大值。这种反应与苯妥英产生的反应形成对比，苯妥英是一种已知与甲状腺素结合球蛋白结合的药物，在给药期间会导致尿T-4排泄增加。
