Martínez de Muöz D, Oscos A
Psychopharmacology (Berl). 1977 Oct 20;54(2):149-52. doi: 10.1007/BF00426771.
Three cyclic analogs of gamma-aminobutyric acid (GABA)-5-ethyl, 5-phenyl, 2-pyrrolidinone (EPP), 5-diphenyl, 2-pyrrolidinone (DPP), and 5-methyl, 5-phenyl, 2-pyrrolidinone (MPP)- were studied in relation to protein synthesis and the latter in relation to discrimination learning. The present study shows that when different groups of rats were injected subcutaneously with 10 mg/kg of EPP or DPP, the protein synthesis in vitro was inhibited 75% in brain mitochondria. MPP at the same doses was the less potent inhibitor of mitochondria protein synthesis. Experiments on discrimination learning show that 10mg/kg of MPP enhance the response decision speed in presence of S(+) (white arm) and S(-) (black arm).
研究了γ-氨基丁酸（GABA）的三种环状类似物——5-乙基-5-苯基-2-吡咯烷酮（EPP）、5-二苯基-2-吡咯烷酮（DPP）和5-甲基-5-苯基-2-吡咯烷酮（MPP）与蛋白质合成的关系，以及蛋白质合成与辨别学习的关系。本研究表明，当不同组的大鼠皮下注射10mg/kg的EPP或DPP时，脑线粒体中的体外蛋白质合成被抑制了75%。相同剂量的MPP对线粒体蛋白质合成的抑制作用较弱。辨别学习实验表明，10mg/kg的MPP在存在S(+)（白色臂）和S(-)（黑色臂）的情况下提高了反应决策速度。
