• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

苯丙胺在猫体内的分布动力学

Kinetics of distribution of amphetamine in cats.

作者信息

Latini R, Placidi G F, Riva E, Fornaro P, Guarneri M, Morselli P L

出版信息

Psychopharmacology (Berl). 1977 Oct 20;54(2):209-15. doi: 10.1007/BF00426782.

DOI:10.1007/BF00426782
PMID:412217
Abstract

The distribution and metabolic fate of amphetamine were studied in cats. In the brain, high levels of drug were detected in the grey matter structures at short intervals after administration, while at longer intervals distribution between white and grey matter areas was more uniform. In peripheral tissues the greatest concentration of the drug was seen in the highly vascularized organs. Para-hydroxy-amphetamine was found in minimal amounts in the liver and kidneys and only at trace quantities in the brain.

摘要

在猫身上研究了苯丙胺的分布和代谢归宿。给药后短时间内,在脑灰质结构中检测到高浓度的药物,而较长时间后,白质和灰质区域之间的分布更为均匀。在周围组织中,在血管高度丰富的器官中发现药物浓度最高。在肝脏和肾脏中发现对羟基苯丙胺的量极少,在脑中仅发现痕量。

相似文献

1
Kinetics of distribution of amphetamine in cats.苯丙胺在猫体内的分布动力学
Psychopharmacology (Berl). 1977 Oct 20;54(2):209-15. doi: 10.1007/BF00426782.
2
A comparative study of the pharmacokinetics of amphetamine.苯丙胺药代动力学的比较研究。
Res Vet Sci. 1973 Mar;14(2):207-15.
3
Brain and plasma concentrations of amphetamine isomers in mice.小鼠体内苯丙胺异构体的脑和血浆浓度。
J Pharmacol Exp Ther. 1978 Sep;206(3):586-94.
4
The regional distribution of d-amphetamine and local glucose utilization in rat brain during continuous amphetamine administration.连续给予苯丙胺期间大鼠脑内右旋苯丙胺的区域分布及局部葡萄糖利用情况。
Exp Brain Res. 1981;43(3-4):281-8. doi: 10.1007/BF00238369.
5
Comparative metabolism of dl-3H-amphetamine hydrochloride in tolerant and nontolerant cats.盐酸消旋-3H-苯丙胺在耐受和未耐受猫体内的代谢比较
Proc West Pharmacol Soc. 1968;11:75-7.
6
Disposition of methamphetamine and its metabolite amphetamine in brain and other tissues in rats after intravenous administration.静脉注射后大鼠脑及其他组织中甲基苯丙胺及其代谢物苯丙胺的分布情况。
J Pharmacol Exp Ther. 2000 Mar;292(3):1042-7.
7
The fate of p-bromo-methylamphetamine (V-111) in the body.对溴甲基苯丙胺(V-111)在体内的代谢情况。
Acta Physiol Acad Sci Hung. 1981;57(3):285-307.
8
Tissue distribution of propafenone in the rat after intravenous administration.静脉注射后普罗帕酮在大鼠体内的组织分布。
Eur J Drug Metab Pharmacokinet. 1991 Jan-Mar;16(1):23-7. doi: 10.1007/BF03189870.
9
The effect of acute and chronic injections of d-amphetamine sulfate and substantia nigra lesions on the distribution of amphetamine and para-hydroxyamphetamine in the rat brain.硫酸右苯丙胺的急性和慢性注射以及黑质损伤对大鼠脑中苯丙胺和对羟基苯丙胺分布的影响。
Life Sci. 1976 Oct 15;19(8):1265-9. doi: 10.1016/0024-3205(76)90262-9.
10
Metabolism of amphetamine by rat brain tissue.大鼠脑组织对苯丙胺的代谢
Biochem Pharmacol. 1978 Feb 1;27(3):343-51. doi: 10.1016/0006-2952(78)90238-1.

引用本文的文献

1
A Case of Amphetamine and Methamphetamine Intoxication in Cat.猫的苯丙胺和甲基苯丙胺中毒病例
Toxics. 2022 Dec 1;10(12):749. doi: 10.3390/toxics10120749.
2
Clinical pharmacology of the perinatal period and early infancy.围产期和婴儿早期的临床药理学。
Clin Pharmacokinet. 1989;17 Suppl 1:13-28. doi: 10.2165/00003088-198900171-00004.

本文引用的文献

1
Sulfur-35 labeled acetazolamide in cat brain.猫脑中的硫-35标记乙酰唑胺。
J Pharmacol Exp Ther. 1959 Feb;125(2):128-36.
2
The local circulation of the living brain; values in the unanesthetized and anesthetized cat.活脑的局部循环;未麻醉和麻醉猫的相关数值。
Trans Am Neurol Assoc. 1955(80th Meeting):125-9.
3
Studies on the distribution and fate of S35-labelled benzylpenicillin in the body.关于S35标记的苄青霉素在体内的分布及转归的研究。
Acta Radiol Suppl. 1954;118:1-110.
4
[Neurophysiological analysis of the central action of d-amphetamine (maxiton)].
Sem Hop. 1954 May 6;30(30):1880-7.
5
Measurement of regional cerebral blood flow with antipyrine-14C in awake cats.用14C-安替比林测量清醒猫的局部脑血流量。
J Appl Physiol. 1969 Aug;27(2):296-300. doi: 10.1152/jappl.1969.27.2.296.
6
Metabolic fate of amphetamine in the cat during development of tolerance.猫对苯丙胺产生耐受性过程中的代谢命运
Arch Int Pharmacodyn Ther. 1971 Mar;190(1):135-49.
7
Caudal dopamine and stereotype behaviour of cats.猫尾部多巴胺与刻板行为
Arch Int Pharmacodyn Ther. 1970 Sep;187(1):163-73.
8
Gas chromatographic determination of amphetamine in blood, tissue, and urine.气相色谱法测定血液、组织和尿液中的苯丙胺。
Scand J Clin Lab Invest. 1970 Sep;26(2):137-43. doi: 10.3109/00365517009049225.
9
Distribution of ( 14 C) amphetamine in mouse brain: an autoradiographic study.(14C)苯丙胺在小鼠脑中的分布:一项放射自显影研究。
Brain Res. 1972 Mar 24;38(2):399-405. doi: 10.1016/0006-8993(72)90722-6.
10
A specific gas chromatographic method for the detection of p-hydroxyamphetamine and p-hydroxynorephedrine in brain tissue.一种用于检测脑组织中对羟基苯丙胺和对羟基去甲麻黄碱的特定气相色谱法。
J Chromatogr. 1973 Sep 26;84(2):355-60. doi: 10.1016/s0021-9673(01)91715-7.