Latini R, Placidi G F, Riva E, Fornaro P, Guarneri M, Morselli P L
Psychopharmacology (Berl). 1977 Oct 20;54(2):209-15. doi: 10.1007/BF00426782.
The distribution and metabolic fate of amphetamine were studied in cats. In the brain, high levels of drug were detected in the grey matter structures at short intervals after administration, while at longer intervals distribution between white and grey matter areas was more uniform. In peripheral tissues the greatest concentration of the drug was seen in the highly vascularized organs. Para-hydroxy-amphetamine was found in minimal amounts in the liver and kidneys and only at trace quantities in the brain.
在猫身上研究了苯丙胺的分布和代谢归宿。给药后短时间内,在脑灰质结构中检测到高浓度的药物,而较长时间后,白质和灰质区域之间的分布更为均匀。在周围组织中,在血管高度丰富的器官中发现药物浓度最高。在肝脏和肾脏中发现对羟基苯丙胺的量极少,在脑中仅发现痕量。