Fakih-Gomez Nabil, Kadouch Jonathan, Obeid Pia Maria, Dagher Elie, Carpinteiro Inês, Muñoz-Gonzalez Cristina
Department of Facial Plastic and Cranio-Maxillo-Facial Surgery, Fakih Hospital, Main Street, Khaizaran, 00000, Lebanon.
Practice for Aesthetic Dermatology, Resculpt Clinic, Amsterdam, The Netherlands.
Aesthetic Plast Surg. 2025 Nov 12. doi: 10.1007/s00266-025-05450-2.
Aging leads to facial volume loss, particularly in the forehead, resulting in a flat appearance and static wrinkles. Effective forehead rejuvenation aims to restore volume while minimizing risks associated with filler injections. Hyaluronic acid (HA) and calcium hydroxylapatite (CaHA) fillers are commonly used, with recent interest in hybrid techniques that combine both to optimize aesthetic outcomes. This study evaluates the efficacy and safety of a premixed hybrid filler approach for forehead rejuvenation.
A multicenter retrospective cohort study analyzed 111 patients (108 females, 3 males) aged 18-43, who received hybrid injections of CaHA (Radiesse) and HA (Belotero Volume) at varying ratios based on forehead contour. The injection volumes and product ratios were customized according to the patients' needs. Follow-ups were conducted at 2 weeks, 3 months, 6 months and 12 months. Primary outcomes were adverse events (AEs) classified per Kadouch criteria; secondary outcomes included patient satisfaction.
The cohort consisted of 108 women (97.2%) and 3 men (2.7%), mean age 30.5 years. The average injected volume was 3.11 mL. Two transient minor AEs (1.8%) were reported: localized hematoma and periorbital edema, both resolving with conservative management. No cases of vascular compromise, nodules, migration, or long-term complications were observed. High patient satisfaction was reported across all evaluations.
The combination of CaHA and HA fillers administered via a retrograde fanning injection technique in the deep forehead fat plane proved to be both safe and effective in improving frontal depressions, with no adverse events reported during the 12 month observation period.
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衰老会导致面部容量减少，尤其是在前额部位，从而导致外观扁平并出现静态皱纹。有效的前额年轻化旨在恢复容量，同时将与填充剂注射相关的风险降至最低。透明质酸（HA）和羟基磷灰石钙（CaHA）填充剂是常用的，最近人们对将两者结合的混合技术产生兴趣，以优化美学效果。本研究评估了一种预混合混合填充剂方法用于前额年轻化的疗效和安全性。
一项多中心回顾性队列研究分析了111名年龄在18至43岁之间的患者（108名女性，3名男性），他们根据前额轮廓接受了不同比例的CaHA（瑞蓝唯瑅）和HA（贝洛特罗极致）混合注射。注射体积和产品比例根据患者需求定制。在2周、3个月、6个月和12个月时进行随访。主要结局是根据卡杜什标准分类的不良事件（AE）；次要结局包括患者满意度。
该队列包括108名女性（97.2%）和3名男性（2.7%），平均年龄30.5岁。平均注射体积为3.11 mL。报告了两例短暂的轻微不良事件（1.8%）：局部血肿和眶周水肿，两者均通过保守治疗得到缓解。未观察到血管受压、结节、移位或长期并发症的病例。在所有评估中均报告了较高的患者满意度。
在额部深层脂肪平面通过逆行扇形注射技术联合使用CaHA和HA填充剂，在改善额部凹陷方面被证明是安全有效的，在12个月的观察期内未报告不良事件。
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