RNA 指导的 DNA 聚合酶与小鼠病毒诱导的白血病
RNA-directed DNA polymerase and virus-induced leukemia in mice.
作者信息
Wu A M, Ting R C, Gallo R C
出版信息
Proc Natl Acad Sci U S A. 1973 May;70(5):1298-302. doi: 10.1073/pnas.70.5.1298.
Abstract
Rifamycin antibiotics, which inhibit RNA-directed DNA polymerase of Rauscher leuckemia virus, prevent the leukemogenic activity of the virus, and the effect of leukemogenesis correlates with the magnitude of inhibition of the purified enzyme. This inhibition of enzyme activity by rifamycin SV derivatives is due to a relatively tight binding between the enzymes and the inhibitors, yet the binding can be reversed by nonionic detergent. The results of this study suggest that RNA-directed DNA polymerase is essential for induction of leukemia by exogenous virus and correlate with the previous observation that the same derivatives block viral transformation in vitro.
摘要
利福霉素抗生素可抑制劳氏白血病病毒的RNA指导的DNA聚合酶，阻止该病毒的致白血病活性，并且白血病发生的效应与纯化酶的抑制程度相关。利福霉素SV衍生物对酶活性的这种抑制作用是由于酶与抑制剂之间相对紧密的结合，然而这种结合可以被非离子去污剂逆转。本研究结果表明，RNA指导的DNA聚合酶对于外源性病毒诱导白血病至关重要，并且与之前观察到的相同衍生物在体外阻断病毒转化的结果相关。
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本文引用的文献
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Selective inhibition by streptovaricin of splenomegaly induced Rauscher leukaemia by virus.链黑菌素对脾肿大诱导的劳斯氏白血病病毒的选择性抑制作用。
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