二甲基苄基利福平作为病毒诱导转化抑制剂的特异性。

The specificity of dimethylbenzylrifampicin as an inhibitor of viral induced transformation.

作者信息

Smith H S, Hackett A J

出版信息

Proc Natl Acad Sci U S A. 1974 Jul;71(7):2770-2. doi: 10.1073/pnas.71.7.2770.

DOI:10.1073/pnas.71.7.2770

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC388552/

Abstract

The effect of 2',6'-dimethyl-N(4')-benzyl-N(4')- [desmethyl]rifampicin on viral transformation induced by two unrelated oncogenic viruses was compared. Transformation of Balb/3T3 cells by the small, DNA-containing papova virus simian virus 40 was completely normal under conditions where transformation by the large, RNA-containing oncornavirus murine sarcoma virus was inhibited more than 150-fold. For these experiments a resistant variant of Balb/3T3 was selected that grows well in high concentrations of the drug, is not dependent on the drug for growth, and is probably not blocked at the level of drug uptake. These data show that dimethyl-benzylrifampicin specifically inhibits oncornavirus-induced transformation rather than nonspecifically inhibiting cellular growth or transformation.

摘要

比较了2',6'-二甲基-N(4')-苄基-N(4')-[去甲基]利福平对两种不相关致癌病毒诱导的病毒转化的影响。在含RNA的大型肿瘤病毒鼠肉瘤病毒诱导的转化被抑制超过150倍的条件下，含DNA的小型乳头多瘤病毒猿猴病毒40对Balb/3T3细胞的转化完全正常。在这些实验中，选择了Balb/3T3的一个抗性变体，它在高浓度药物中生长良好，生长不依赖于药物，并且可能在药物摄取水平上没有被阻断。这些数据表明，二甲基苄基利福平特异性抑制肿瘤病毒诱导的转化，而不是非特异性抑制细胞生长或转化。

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本文引用的文献

1

RNA dependent DNA polymerase of human acute leukaemic cells.人类急性白血病细胞的RNA依赖性DNA聚合酶

Nature. 1970 Dec 5;228(5275):927-9. doi: 10.1038/228927a0.

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Synthesis of some rifamycin derivatives as inhibitors of an RNA-instructed DNA polymerase function.一些利福霉素衍生物作为RNA指导的DNA聚合酶功能抑制剂的合成。

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Synergistic effect of rifamycin derivatives and amphotericin B on viral transformation of a murine cell line.利福霉素衍生物与两性霉素B对小鼠细胞系病毒转化的协同作用。

Proc Natl Acad Sci U S A. 1972 Dec;69(12):3653-4. doi: 10.1073/pnas.69.12.3653.

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Inhibition of MLV-induced transformation in Balb-3T3 derived cells.抑制莫洛尼氏鼠白血病病毒（MLV）诱导的Balb-3T3衍生细胞的转化。

Nat New Biol. 1972 Oct 11;239(93):166-7. doi: 10.1038/newbio239166a0.

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Cell line derived from Balb-3T3 that is transformed by murine leukaemia virus: a focus assay for leukaemia virus.源自Balb - 3T3且被鼠白血病病毒转化的细胞系：一种用于白血病病毒的焦点检测法。

Nat New Biol. 1972 Oct 11;239(93):164-6. doi: 10.1038/newbio239164a0.

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3-Cyclic amine derivatives of rifamycin: strong inhibitors of the DNA polymerase activity of RNA tumor viruses.利福霉素的3-环胺衍生物：RNA肿瘤病毒DNA聚合酶活性的强效抑制剂。

Proc Natl Acad Sci U S A. 1972 May;69(5):1294-8. doi: 10.1073/pnas.69.5.1294.

7

Reverse transciptase from Mason-Pfizer monkey tumor virus, avian myeloblastosis virus, and Rauscher leukemia virus and its response to rifamycin derivatives.来自梅森- Pfizer猴肿瘤病毒、禽成髓细胞瘤病毒和劳氏肉瘤病毒的逆转录酶及其对利福霉素衍生物的反应。

J Natl Cancer Inst. 1972 Apr;48(4):1185-9.

8

Inhibition of MSV viral function by rifampicin derivatives.利福平衍生物对MSV病毒功能的抑制作用。

Medicine (Baltimore). 1972 May;51(3):175-80. doi: 10.1097/00005792-197205000-00003.

9

Effect of rifampicin and two of its derivatives on cells infected with Moloney sarcoma virus.利福平及其两种衍生物对感染莫洛尼肉瘤病毒的细胞的影响。

Proc Natl Acad Sci U S A. 1971 Jul;68(7):1441-3. doi: 10.1073/pnas.68.7.1441.

10

Inhibitors of the RNA and DNA dependent polymerase activities of RNA tumour viruses.RNA肿瘤病毒的RNA和DNA依赖性聚合酶活性抑制剂。

Nat New Biol. 1971 Jan 27;229(4):111-4. doi: 10.1038/newbio229111a0.

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