Selimov M A, El'bert L B, Aksenova T A, Kliueva E V, Gribencha L F
Vopr Virusol. 1977 Sep-Oct(5):581-5.
Humoral response (virus-neutralizing antibody production) to immunization with inactivated 30-fold concentrated and purified tissue culture rabies vaccine was studied in monkeys and human volunteers. Two doses of the preparation spaced 20 days apart and given intramuscularly or intradermally to monkeys induced in them much more intensive antibody production (4--213-fold by titer) than 6 daily injections of unconcentrated vaccine. In 10 human volunteers immunized with 1.5 ml doses of the concentrated vaccine intramuscularly twice 20 days apart antibody titers 40 days after immunization varied from 1:79 to 1:6250 (average 1:1067). In another group of 10 human volunteers immunized intramuscularly with the concentrated vaccine 3 times at 0, 1st and 20th day, antibody titers 40 days after immunization were 1:112--1:3273 (average 1:508). These values are significantly higher than the average titers in humans vaccinated with unconcentrated tissue culture of brain vaccine of Fermi type. The concentrated vaccine proved to be a preparation of low reactogenicity: no systemic reactions were observed among vaccinated volunteers; 4 out of 20 volunteers had a mild, transient (1 day) local reaction (hyperemia of less than 1.5 cm in diameter).
在猴子和人类志愿者中研究了用灭活的30倍浓缩纯化组织培养狂犬病疫苗免疫后的体液反应（病毒中和抗体产生）。间隔20天肌肉注射或皮内注射两剂该制剂，在猴子中诱导产生的抗体水平（滴度提高4至213倍）比每天注射6次未浓缩疫苗更为强烈。10名人类志愿者间隔20天肌肉注射1.5毫升剂量的浓缩疫苗两次，免疫后40天抗体滴度在1:79至1:6250之间（平均1:1067）。另一组10名人类志愿者在第0、1和20天肌肉注射浓缩疫苗3次，免疫后40天抗体滴度为1:112至1:3273（平均1:508）。这些数值显著高于接种费米型未浓缩脑疫苗组织培养的人类的平均滴度。浓缩疫苗被证明是一种低反应原性制剂：接种志愿者中未观察到全身反应；20名志愿者中有4人出现轻微、短暂（1天）的局部反应（直径小于1.5厘米的充血）。
