芳基乙酸的代谢。2. [14C] 氢化阿托酸的归宿及其种间差异。

Metabolism of arylacetic acids. 2. The fate of [14C]hydratropic acid and its variation with species.

Dixon P A, Caldwell J, Smith R L

Xenobiotica. 1977 Nov;7(11):707-15. doi: 10.3109/00498257709038700.

Abstract

(+/-)-[methyl-14C]-Hydratropic acid was administered to man, rhesus monkey, cat, rabbit and fruit bat. 2. All species excreted 60-100% of administered 14C in the urine in 24 h, and unchanged hydratropic acid accounted for 0-17% of the dose. 3. In man, the urinary 14C consisted of a very small quantity (1%) of unchanged hydratropic acid with the remainder as hydratropylglucuronide. 4. Hydratropylglucuronide was the major urinary excretion product in the 4 animal species, while the glycine conjugate was present in the urine of cat and rat. Additionally, cats excreted the taurine conjugate of hydratropic acid. 5. Bile-duct cannulated rats excreted 20-30% of an injected dose of [14C] hydratropic acid in the bile in 3 h mainly as hydratropylglucuronide.

摘要

给人、恒河猴、猫、兔和果蝠施用（±）-[甲基 - 14C] - 氢化阿托酸。2. 所有物种在24小时内将所施用14C的60 - 100%经尿液排出，未变化的氢化阿托酸占剂量的0 - 17%。3. 在人体中，尿中14C由极少量（1%）未变化的氢化阿托酸组成，其余为氢化阿托基葡糖醛酸。4. 氢化阿托基葡糖醛酸是这4种动物物种尿液中的主要排泄产物，而甘氨酸结合物存在于猫和大鼠的尿液中。此外，猫还排泄氢化阿托酸的牛磺酸结合物。5. 胆管插管大鼠在3小时内将注射剂量的[14C]氢化阿托酸的20 - 30%经胆汁排出，主要为氢化阿托基葡糖醛酸。