Feldman G L, Weaver D D, Lovrien E W
Am J Dis Child. 1977 Dec;131(12):1389-92. doi: 10.1001/archpedi.1977.02120250071012.
We describe a family in which seven pregnancies resulted in four infants who died and in three abortions. During these pregnancies the mother took trimethadione (Tridione), as well as other anticonvulsants. Two normal children were born after treatment with all medications were stopped. There have now been 53 reported pregnancies in which the fetuses were exposed to trimethadione or paramethadione; 48 (87%) resulted in fetal loss or a child born with congenital malformations. The most common defects include malformed ears, cleft palate, cardiac defects, urogenital malformations, and skeletal abnormalities. Delayed mental and physical development were also seen. These findings constitute a clinical entity termed the fetal trimethadione syndrome. The malformation rate is believed to be due to the teratogenic effects of trimethadione. Physicians need to be aware of the danger of trimethadione and related drugs during pregnancy and should withhold these medications during this period.
我们描述了这样一个家庭，其中七次怀孕导致四名婴儿死亡和三次流产。在这些孕期中，母亲服用了三甲双酮（曲二酮）以及其他抗惊厥药。在停止所有药物治疗后，两名正常儿童出生。目前已有53例报告的孕期案例，其中胎儿接触了三甲双酮或对甲双酮；48例（87%）导致胎儿丢失或出生的孩子患有先天性畸形。最常见的缺陷包括耳部畸形、腭裂、心脏缺陷、泌尿生殖系统畸形和骨骼异常。还观察到智力和身体发育迟缓。这些发现构成了一种临床病症，称为胎儿三甲双酮综合征。畸形率被认为是由三甲双酮的致畸作用所致。医生需要意识到孕期使用三甲双酮及相关药物的危险性，在此期间应停用这些药物。
