胚胎大鼠肝脏中的尿苷激酶。5-氮杂胞苷对酶活性的调节。
Uridine kinase in embryonic rat liver. Modulation of enzyme activity by 5-azacytidine.
作者信息
Veselý J, Cihák A
出版信息
Biochem J. 1973 Aug;133(4):609-13. doi: 10.1042/bj1330609d.
Abstract
Uridine kinase activity in rat liver decreases during embryonic and postnatal development. Administration of 5-azacytidine enhances liver uridine kinase activity in adult rats, but depresses it in embryos. The liver enzymes from the foetus and the adult are precipitated at different (NH(4))(2)SO(4) concentrations although they are eluted at about the same position on chromatography on a column of Sepharose 6B.
摘要
大鼠肝脏中的尿苷激酶活性在胚胎期和出生后发育过程中会降低。给予5-氮杂胞苷可增强成年大鼠肝脏中的尿苷激酶活性，但会降低胚胎中的该活性。尽管胎儿和成年大鼠肝脏中的酶在琼脂糖6B柱上进行色谱分析时在大致相同的位置被洗脱，但它们在不同的硫酸铵浓度下沉淀。
相似文献
1
Uridine kinase in embryonic rat liver. Modulation of enzyme activity by 5-azacytidine.胚胎大鼠肝脏中的尿苷激酶。5-氮杂胞苷对酶活性的调节。
Biochem J. 1973 Aug;133(4):609-13. doi: 10.1042/bj1330609d.
2
3
Character of the stimulatory response of uridine kinase in rat livers to cycloheximide treatment.大鼠肝脏中尿苷激酶对环己酰亚胺处理的刺激反应特性。
Eur J Biochem. 1975 Oct 1;58(1):3-7. doi: 10.1111/j.1432-1033.1975.tb02341.x.
4
Activity of uridine kinase in different lines of AKR leukemic mice and its relation to chemotherapy with 5-azacytidine.AKR白血病小鼠不同品系中尿苷激酶的活性及其与5-氮杂胞苷化疗的关系。
Int J Cancer. 1974 Dec 15;14(6):826-32. doi: 10.1002/ijc.2910140617.
5
5-azacytidine-modified patterns of uridine kinase activities in normal and neoplastic tissues.正常组织和肿瘤组织中尿苷激酶活性的5-氮杂胞苷修饰模式。
Cancer Res. 1974 Sep;34(9):2260-5.
6
Stimulatory effect of cycloheximide and related glutarimide antibiotics on liver uridine kinase.
FEBS Lett. 1972 Jun 15;23(2):271-4. doi: 10.1016/0014-5793(72)80359-4.
7
Enhancement of rat liver uridine kinase activity by various metabolic inhibitors.多种代谢抑制剂对大鼠肝脏尿苷激酶活性的增强作用。
Biochem Pharmacol. 1974 Mar 15;23(6):1087-94. doi: 10.1016/0006-2952(74)90009-4.
8
Uridine-cytidine kinase. IV. Kinetics of the competition between 5-azacytidine and the two natural substrates.
Mol Pharmacol. 1979 Mar;15(2):331-40.
9
Alterations in differentiation and pyrimidine pathway enzymes in 5-azacytidine resistant variants of a myoblast line.成肌细胞系的5-氮杂胞苷抗性变体中分化和嘧啶途径酶的改变。
J Cell Physiol. 1977 Feb;90(2):361-47. doi: 10.1002/jcp.1040900221.
10
Prolongation of the lag period preceding the enhancement of thymidine and thymidylate kinase activity in regenerating rat liver by 5-azacytidine.5-氮杂胞苷对再生大鼠肝脏中胸苷和胸苷酸激酶活性增强之前的延迟期的延长作用。
Biochem Pharmacol. 1972 Dec 15;21(24):3257-65. doi: 10.1016/0006-2952(72)90090-1.
引用本文的文献
1
Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases.人脱氧核糖核苷激酶和核糖核苷激酶对抗病毒和抗癌核苷类似物的底物特异性及磷酸化作用
Pharmacol Ther. 2003 Nov;100(2):119-39. doi: 10.1016/j.pharmthera.2003.07.001.
本文引用的文献
1
2
FEEDBACK INHIBITION OF URIDINE KINASE BY CYTIDINE TRIPHOSPHATE AND URIDINE TRIPHOSPHATE.胞苷三磷酸和尿苷三磷酸对尿苷激酶的反馈抑制作用
Biochim Biophys Acta. 1964 Nov 15;91:380-6. doi: 10.1016/0926-6550(64)90067-2.
3
FREE RIBOSOMES DURING MATURATION OF RAT LIVER.大鼠肝脏成熟过程中的游离核糖体。
Comp Biochem Physiol. 1963 Sep;10:33-8. doi: 10.1016/0010-406x(63)90100-2.
4
STUDIES ON RESISTANCE AGAINST 5-FLUOROURACIL. IV. EVIDENCE FOR AN ALTERED URIDINE KINASE IN RESISTANT CELLS.对5-氟尿嘧啶耐药性的研究。IV. 耐药细胞中尿苷激酶改变的证据。
Biochim Biophys Acta. 1963 Sep 17;76:160-2. doi: 10.1016/0006-3002(63)90025-8.
5
Alterations in pyrimidine metabolism in L5178Y leukemia cells resistant to 6-azauridine.对6-氮杂尿苷耐药的L5178Y白血病细胞中嘧啶代谢的改变。
Cancer Res. 1961 Jan;21:110-7.
6
Partial reversal of toxic effects of 5-azacytidine by 6-azauridine in normal mice.6-氮杂尿苷对正常小鼠5-氮杂胞苷毒性作用的部分逆转
Experientia. 1965 Oct 15;21(10):581-2. doi: 10.1007/BF02151543.
7
Regulation of enzymic activity by metabolites. I. Uridine-cytidine kinase of Novikoff ascites rat tumor.代谢物对酶活性的调节。I. 诺维科夫腹水大鼠肿瘤的尿苷 - 胞苷激酶
J Biol Chem. 1969 Apr 25;244(8):2204-9.
8
9
10
Enhanced stability of uridine kinase from mouse leukemic cells resistant to 5-azacytidine. Thermal inactivation and effect of p-chloromercuribenzoate.对5-氮杂胞苷耐药的小鼠白血病细胞中尿苷激酶稳定性增强。热失活及对氯汞苯甲酸的影响。
Eur J Biochem. 1971 Oct 26;22(4):551-6. doi: 10.1111/j.1432-1033.1971.tb01576.x.
Zotero 插件