Kawahara R, Umezawa Y, Fukuhara T, Funakoshi S, Kuba K
Folia Psychiatr Neurol Jpn. 1977;31(3):429-35. doi: 10.1111/j.1440-1819.1977.tb02629.x.
The subjects of this study consisted of 17 epileptic patients with clinical seizures during all-night sleep recording (the seizure group) and another 17 epileptic patients without clinical seizures (the control group). The results obtained were as follows: 1) The 50-90% out of total clinical seizures were induced in non-REM sleep, while a few clinical seizures were induced in REM sleep. The number of clinical seizures in sleep stage of higher activity level increased as the incidence of clinical seizure during all-night grew. 2) In the seizure group REM sleep could not be detectable during all-night in five cases out of 17 cases, while we could not find cases lacking REM sleep in the control group. This difference between two subject groups was statistically significant (P less than 0.025). 3) As to focal spike group, the spike discharge incidence of total sleeping time and of each sleep stage was higher respectively in the seizure group than that in the control group, and particularly in St.1, St.2 and REM sleep the figure of the discharge incidence was found significantly higher in the seizure group than that in the control group (P less than 0.05). We discussed on above-mentioned results, and we emphasized particularly that REM-sleep suppresses clinical seizures, although non-REM sleep induces clinical seizures.
本研究的对象包括17例在全夜睡眠记录期间有临床发作的癫痫患者（发作组）和另外17例无临床发作的癫痫患者（对照组）。所得结果如下：1）50% - 90%的临床发作在非快速眼动睡眠期诱发，而少数临床发作在快速眼动睡眠期诱发。随着全夜临床发作发生率的增加，活动水平较高睡眠阶段的临床发作次数也增加。2）在发作组中，17例中有5例在全夜睡眠期间无法检测到快速眼动睡眠，而在对照组中未发现缺乏快速眼动睡眠的病例。两个受试组之间的这种差异具有统计学意义（P小于0.025）。3）对于局灶性棘波组，发作组总睡眠时间和各睡眠阶段的棘波放电发生率分别高于对照组，特别是在第1期、第2期和快速眼动睡眠期，发作组的放电发生率显著高于对照组（P小于0.05）。我们对上述结果进行了讨论，并特别强调，尽管非快速眼动睡眠会诱发临床发作，但快速眼动睡眠会抑制临床发作。
