大鼠被动皮肤过敏反应（PCA）模型与猴哮喘模型中预先给予抗过敏化合物的效果差异。PRD - 92 - Ea与色甘酸二钠效果的比较。
The difference in effect of predosing with antiallergic compounds between the rat PCA model and the monkey asthma model. Comparison of the effects of PRD-92-Ea and disodium cromoglycate.
作者信息
El-Azab J, Stewart P B
出版信息
Int Arch Allergy Appl Immunol. 1977;55(1-6):343-9. doi: 10.1159/000231945.
DSCG and PRD-92-Ea showed tachyphylaxis in the rat PCA test when a large intravenous dose (40 mg/kg of DSCG and 20 mg/kg of PRD-92-Ea) was given 30 min before administering intravenously the expected effective doses at the time of antigen challenge. This predosing led to a marked loss of effectiveness. Cross-reacting tachyphylaxis was also demonstrated in this model. Predosing rats with DSCG led to a great loss of effectiveness of a subsequent expected active dose of PRD-92-Ea and predosing with PRD-92-Ea had the same effect in preventing the antiallergic action of a subsequent dose of DSCG. The Rhesus monkey (Macaca mulatta) did not exhibit this phenomenon of tachyphylaxis. PRD-92-Ea and DSCG were given intravenously 30 min before and the same dose of 20 mg/kg repeated just before Ascaris suum challenge in the Rhesus monkey asthma model with no loss of their expected effectiveness.
在大鼠PCA试验中，当在静脉注射抗原激发时预期有效剂量前30分钟给予大剂量静脉注射（DSCG 40mg/kg和PRD - 92 - Ea 20mg/kg）时，DSCG和PRD - 92 - Ea显示出快速耐受性。这种预先给药导致明显的有效性丧失。在该模型中也证明了交叉反应性快速耐受性。用DSCG预先给药大鼠导致随后预期活性剂量的PRD - 92 - Ea有效性大幅丧失，而用PRD - 92 - Ea预先给药在预防随后剂量的DSCG的抗过敏作用方面具有相同效果。恒河猴（猕猴）未表现出这种快速耐受性现象。在恒河猴哮喘模型中，在感染猪蛔虫前30分钟静脉注射PRD - 92 - Ea和DSCG，并在即将感染前重复给予相同剂量20mg/kg，其预期有效性未丧失。
Zotero 插件