抗原在淋巴滤泡中捕获的非特异性性质。
Nonspecific nature of antigen trapping in lymphoid follicles.
作者信息
van Rooijen N
出版信息
Immunology. 1973 Nov;25(5):853-67.
The localization of two labelled antigens in the rabbit spleen was compared at different time intervals after their intravenous injection. By using a special autoradiographic technique I-HGG and H-DNP-BGG could be distinguished in the same tissue section. In a normal rabbit as well as in a rabbit preimmunized against the antigens, both antigens were found in the same sites of the follicles 2.5 hours, 1 day and 8 days after their injection. The results confirm that as far as cells are involved in the process of antigen trapping in lymphoid follicles of the spleen, they are not monospecific for a particular antigen. Results are discussed in relation to the mechanism of antigen trapping and the transport of antigens towards the follicle centres.
在静脉注射两种标记抗原后，于不同时间间隔对家兔脾脏中这两种抗原的定位进行了比较。通过使用一种特殊的放射自显影技术，在同一组织切片中可以区分I-HGG和H-DNP-BGG。在正常家兔以及预先针对这些抗原进行免疫的家兔中，注射后2.5小时、1天和8天，两种抗原均在滤泡的相同部位被发现。结果证实，就参与脾脏淋巴滤泡中抗原捕获过程的细胞而言，它们并非对特定抗原具有单特异性。结合抗原捕获机制以及抗原向滤泡中心的转运对结果进行了讨论。
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