禽白血病-肉瘤病毒、网状内皮组织增殖症病毒的RNA与鸡内源性RNA指导的DNA聚合酶活性之间缺乏序列同源性。
Lack of sequence homology among RNAs of avian leukosis-sarcoma viruses, reticuloendotheliosis viruses, and chicken endogenous RNA-directed DNA polymerase activity.
作者信息
Kang C Y, Temin H M
出版信息
J Virol. 1973 Dec;12(6):1314-24. doi: 10.1128/JVI.12.6.1314-1324.1973.
Abstract
The relatedness of the RNAs of the three avian systems, including six avian leukosis-sarcoma viruses, four reticuloendotheliosis viruses, and the microsome fraction of normal uninfected chicken embryo cells, containing RNA and a DNA polymerase have been studied by nucleic acid hybridization. All six avian leukosis-sarcoma viruses have closely related nucleotide sequences; and all four reticuloendotheliosis viruses have closely related nucleotide sequences. But, almost no similarities were detected between the RNAs of avian leukosis-sarcoma viruses and reticuloendotheliosis viruses. The RNA template of the endogenous RNA-directed DNA polymerase activity of normal uninfected chicken cells had no detectable relationship to RNAs of avian leukosis-sarcoma and reticuloendotheliosis viruses.
摘要
通过核酸杂交研究了三种禽类系统的RNA之间的相关性，这三种禽类系统包括六种禽白血病-肉瘤病毒、四种网状内皮组织增殖症病毒，以及正常未感染鸡胚细胞的微粒体部分（其含有RNA和一种DNA聚合酶）。所有六种禽白血病-肉瘤病毒都具有密切相关的核苷酸序列；所有四种网状内皮组织增殖症病毒也都具有密切相关的核苷酸序列。但是，在禽白血病-肉瘤病毒和网状内皮组织增殖症病毒的RNA之间几乎未检测到相似性。正常未感染鸡细胞的内源性RNA指导的DNA聚合酶活性的RNA模板与禽白血病-肉瘤病毒和网状内皮组织增殖症病毒的RNA没有可检测到的关系。
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