用A-2斑块病毒免疫实验动物诱导乙肝抗体

Shaw E D, McKee A P, Rancourt M, Hollenbeck L

J Virol. 1973 Dec;12(6):1598-607. doi: 10.1128/JVI.12.6.1598-1607.1973.

A sero-conversion for hepatitis B antibody has resulted from immunization of patas monkeys, guinea pigs, and rabbits with the A-2 plaque virus. This agent was isolated in tissue culture from patient sera that were positive for hepatitis B antigen. The immune response was assayed with techniques of direct and indirect counter-immunoelectrophoresis, and immune electron microscopy.

用A - 2噬菌斑病毒对粗尾猿猴、豚鼠和兔子进行免疫接种后，出现了乙肝抗体血清转化。该病原体是从乙肝抗原呈阳性的患者血清中通过组织培养分离出来的。采用直接和间接对流免疫电泳技术以及免疫电子显微镜技术对免疫反应进行了检测。