吗啡与大鼠穿梭箱自我刺激：一种欣快感模型
Morphine and shuttle-box self-stimulation in the rat: a model for euphoria.
作者信息
Levitt R A, Baltzer J H, Evers T M, Stilwell D J, Furby J E
出版信息
Psychopharmacology (Berl). 1977 Nov 15;54(3):307-11. doi: 10.1007/BF00426581.
PMID:413150
Abstract
In a shuttle-box self-stimulation paradigm, analgesic doses of morphine increase the amount of time a rat leaves rewarding brain stimulation on, without altering average OFF times. This paradigm may serve as a model for the euphoria induced by narcotic drugs and as a useful tool for evaluating the reinforcing effects of drugs.
摘要
在穿梭箱自我刺激范式中，镇痛剂量的吗啡会增加大鼠保持奖励性脑刺激开启的时间，而不会改变平均关闭时间。这种范式可作为麻醉药物诱发欣快感的模型，以及评估药物强化作用的有用工具。
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