大鼠体内麻醉拮抗剂（纳洛酮）与麦角酸二乙酰胺（LSD）之间的相互作用。
Interaction between narcotic antagonist (naloxone) and lysergic acid diethylamide (LSD) in the rat.
作者信息
Fertziger A P, Fischer R
出版信息
Psychopharmacology (Berl). 1977 Nov 15;54(3):313-4. doi: 10.1007/BF00426582.
PMID:413151
Abstract
LSD administration in rats elicited a diphasic reaction consisting of a brief excitable period ( up to 8 min) followed by a prolonged catalepsy (8 min-1 h). While the cataleptic response was antagonized by a single injection of naloxone (given 30 min after LSD administration), pretreatment with naloxone shortened the excitable phase and potentiated the catalepsy.
摘要
给大鼠注射麦角酸二乙酰胺（LSD）会引发双相反应，包括一个短暂的兴奋期（长达8分钟），随后是长时间的僵住症（8分钟至1小时）。虽然单次注射纳洛酮（在给予LSD后30分钟注射）可拮抗僵住症反应，但用纳洛酮预处理可缩短兴奋期并增强僵住症。
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