Kew M C, Purves L R, Bersohn I
Gut. 1973 Dec;14(12):939-42. doi: 10.1136/gut.14.12.939.
Serum alpha-fetoprotein levels were measured serially by radioimmunoassay in 32 patients with acute viral hepatitis. With one exception, the levels were increased during the course of the illness. Raised concentrations of the protein occurred almost equally in patients with and without the hepatitis-B antigen. In the majority of patients the rise was modest but in seven levels were reached at which alpha-fetoprotein could be detected by immunodiffusion. Very high levels were more likely to occur in children. In eight patients the concentration increased as the serum glutamic pyruvic transaminase (SGPT) level, used as an index of hepatocyte damage, was returning to normal, a pattern which favoured increased synthesis of the protein during hepatocellular regeneration. In the remainder, the alpha-fetoprotein level paralleled that of SGPT, suggesting rather an acutephase reaction to liver injury.
采用放射免疫分析法对32例急性病毒性肝炎患者的血清甲胎蛋白水平进行了连续检测。除1例患者外，其余患者在病程中该水平均升高。无论有无乙型肝炎抗原，患者体内该蛋白浓度均有升高。大多数患者的升高幅度较小，但有7例患者的甲胎蛋白水平升高至可通过免疫扩散法检测到的程度。儿童更易出现甲胎蛋白水平极高的情况。在8例患者中，作为肝细胞损伤指标的血清谷丙转氨酶（SGPT）水平恢复正常时，甲胎蛋白浓度却升高，这种模式表明在肝细胞再生过程中甲胎蛋白合成增加。其余患者的甲胎蛋白水平与SGPT水平平行，提示这更像是对肝损伤的急性期反应。
