Pribnow J F, Hall J M, Besemer D J, Vedros N A
Infect Immun. 1974 Apr;9(4):734-9. doi: 10.1128/iai.9.4.734-739.1974.
Both eyes of rabbits whose right eyes had previously been injected with Neisseria meningitidis were injected with Diplococcus pneumoniae. The pneumococci failed to grow in the right eye of most rabbits challenged 2 and 4 days after the injection of the meningococci, but grew well in all left eyes. The "protective" effect was less pronounced in the rabbits challenged on days 6 and 9 and virtually absent when the interval between the two injections was 14 or 22 days. Pneumococci grew equally well in both eyes of rabbits that had received nitrogen mustard treatment prior to the intravitreal injection of meningococci, indicating a possible role for the polymorphonuclear leukocyte in the protective effect.
曾在右眼注射过脑膜炎奈瑟菌的兔子双眼均注射肺炎链球菌。在注射脑膜炎奈瑟菌后2天和4天接受挑战的大多数兔子中,肺炎链球菌在右眼未能生长,但在所有左眼均生长良好。在第6天和第9天接受挑战的兔子中,“保护”作用不那么明显,而当两次注射的间隔为14天或22天时,这种作用几乎不存在。在玻璃体内注射脑膜炎奈瑟菌之前接受过氮芥治疗的兔子双眼,肺炎链球菌生长情况相同,这表明多形核白细胞在保护作用中可能发挥作用。