Nyka W
Infect Immun. 1974 May;9(5):843-50. doi: 10.1128/iai.9.5.843-850.1974.
Ten cultures of Mycobacterium tuberculosis, one of Mycobacterium kansasii (nonsignificant), and one of Mycobacterium phlei were submitted to starvation. As a result they lost first their acid fastness and then all other staining affinities but, in this chromophobic state, they survived for at least 2 years and, after that time, produced cultures of acid-fast bacilli when transferred onto nutrient media. Chromophobic tubercle bacilli similar to those produced experimentally had previously been demonstrated in caseous lesions of lungs surgically removed from patients under chemotherapy. Since it has been shown that experimentally produced chromophobic bacilli can recover their original biological properties, the opinion is warranted that, under suitable conditions, those in the lung could also become reactivated and cause a relapse of the disease.
十株结核分枝杆菌培养物、一株堪萨斯分枝杆菌（无显著意义）培养物和一株草分枝杆菌培养物被置于饥饿状态。结果，它们首先失去抗酸性，然后失去所有其他染色亲和力，但在这种拒色状态下，它们存活了至少两年，之后转移到营养培养基上时产生了抗酸杆菌培养物。与实验产生的类似的拒色结核杆菌此前已在接受化疗的患者手术切除的肺部干酪样病变中得到证实。由于已经表明实验产生的拒色杆菌可以恢复其原始生物学特性，因此有理由认为，在合适的条件下，肺部的那些拒色杆菌也可能重新激活并导致疾病复发。
