灵长类动物静脉 - 动脉体外循环期间通过右腋动脉灌注实现脑循环和冠状动脉循环的氧合。

Oxygenation of the cerebral and coronary circulation with right axillary artery perfusion during venoarterial bypass in primates.

作者信息

Wickline S A, Soeter J R, McNamara J J

出版信息

Ann Thorac Surg. 1977 Dec;24(6):560-5. doi: 10.1016/s0003-4975(10)63458-3.

Abstract

The effectiveness of right axillary artery perform in delivering oxygenated blood to the cerebral and coronary circulation during venoarterial bypass in primates was studied. Both right and left common carotid flow measurements and arterial gas measurements revealed high flows and elevated PO2 levels. Incomplete mixing in the ascending aorta was observed from cineangiograms taken at various pump oxygenator flows in 1 animal. The results demonstrated that the brain receives excellent oxygenation at all bypass levels. However, the coronary circulation is perfused primarily by blood ejected from the left ventricle and receives only minimal contribution of well-oxygenated blood from the pump oxygenator circuit. Therefore, the heart may suffer prolonged hypoxemia during long-term venoarterial bypass for acute respiratory insufficiency.

摘要

研究了灵长类动物在静脉 - 动脉体外循环期间右腋动脉在向脑循环和冠状动脉循环输送含氧血液方面的有效性。右侧和左侧颈总动脉血流测量以及动脉血气测量均显示血流量高且动脉血氧分压水平升高。在1只动物中，在不同的泵氧合器流量下拍摄的电影血管造影显示升主动脉存在不完全混合。结果表明，在所有体外循环水平下，大脑都能获得良好的氧合。然而，冠状动脉循环主要由左心室射出的血液灌注，仅从泵氧合器回路接受极少部分充分氧合的血液。因此，在急性呼吸功能不全的长期静脉 - 动脉体外循环期间，心脏可能会遭受长时间的低氧血症。