尿苷二磷酸N-乙酰葡糖胺及微粒体破坏对类固醇葡萄糖醛酸化的刺激作用
Stimulation of steroid glucuronidation by uridine diphosphate N-acetylglucosamine and by microsomal disruption.
作者信息
Wilkinson J, Hallinan T
出版信息
Biochem J. 1977 Oct 15;168(1):125-7. doi: 10.1042/bj1680125.
Abstract
Glucuronidation of oestrone and of oestradiol in microsomal fractions was markedly and significantly stimulated by UDP-N-acetylglucosamine and by ultrasonication: Triton X-100 also stimulated. This is consistent with compartmentation of UDP-glucuronyl-transferase. Stimulation by UDP-N-acetylglucosamine may be physiologically significant.
摘要
微粒体组分中雌酮和雌二醇的葡萄糖醛酸化作用受到UDP-N-乙酰葡糖胺和超声处理的显著刺激：Triton X-100也有刺激作用。这与UDP-葡糖醛酸基转移酶的区室化相一致。UDP-N-乙酰葡糖胺的刺激作用可能具有生理意义。
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引用本文的文献
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本文引用的文献
1
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Biochim Biophys Acta. 1972 Nov 10;289(1):88-96. doi: 10.1016/0005-2744(72)90111-8.
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Spontaneous and detergent activation of a glucuronyltransferase in vitro.体外葡糖醛酸基转移酶的自发激活和去污剂激活
Arch Biochem Biophys. 1967 Apr;120(1):198-203. doi: 10.1016/0003-9861(67)90614-5.
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Effects of metals on the properties of hepatic microsomal uridine diphosphate glucuronyltransferase.金属对肝微粒体尿苷二磷酸葡萄糖醛酸基转移酶性质的影响。
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5
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