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1
Common antigenic structures of HL-A antigens. II. Small fragments derived from papain-solubilized HL-A antigen molecules.HL - A抗原的共同抗原结构。II. 源自木瓜蛋白酶可溶解的HL - A抗原分子的小片段
Immunology. 1974 Jan;26(1):155-68.
2
Common antigenic structures of HL-A antigens. VI. Common antigenic determinants located on the 33,000 Dalton alloantigenic fragment portion of papain-solubilized HL-A molecules.HL-A抗原的共同抗原结构。VI. 位于木瓜蛋白酶可溶解的HL-A分子的33,000道尔顿同种异体抗原片段部分上的共同抗原决定簇。
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3
Common antigen structures of HL-A antigens. I. Antigenic determinants recognizable by rabbits on papain-solubilized HL-A molecular fragments.HL-A抗原的共同抗原结构。I. 兔可识别的木瓜蛋白酶溶解的HL-A分子片段上的抗原决定簇。
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4
Structure of HL-A histocompatibility antigens. The structural components of papain-solubilized HL-A antigen molecules.HL-A组织相容性抗原的结构。木瓜蛋白酶可溶解的HL-A抗原分子的结构成分。
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5
Characterization of soluble substances in plasma carrying HL-A alloantigenic activity and HL-A common antigenic activity.携带HL - A同种抗原活性和HL - A共同抗原活性的血浆中可溶性物质的特性分析。
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Common antigenic structures of HL-A antigens. 3. An HL-A common antigenic marker closely associated with HL-A alloantigenic activity and detected by use of rabbit anti-rhesus monkey cell membrane antibodies.HL-A抗原的共同抗原结构。3. 一种与HL-A同种异体抗原活性密切相关的HL-A共同抗原标志物，通过使用兔抗恒河猴细胞膜抗体检测到。
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8
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Proc Natl Acad Sci U S A. 1974 Jan;71(1):35-9. doi: 10.1073/pnas.71.1.35.

引用本文的文献

1
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2
Common antigenic structures of HL-A antigens. IV. HL-A common portion fragment isolated from spent culture medium of human lymphoid cell lines.HL-A抗原的共同抗原结构。IV. 从人淋巴母细胞系的用过的培养基中分离出的HL-A共同部分片段。
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3
Common antigenic structures of HL-A antigens. 3. An HL-A common antigenic marker closely associated with HL-A alloantigenic activity and detected by use of rabbit anti-rhesus monkey cell membrane antibodies.HL-A抗原的共同抗原结构。3. 一种与HL-A同种异体抗原活性密切相关的HL-A共同抗原标志物，通过使用兔抗恒河猴细胞膜抗体检测到。
Immunology. 1974 Sep;27(3):487-500.
4
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5
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Proc Natl Acad Sci U S A. 1975 Apr;72(4):1594-8. doi: 10.1073/pnas.72.4.1594.
6
Plasma-membrane-associated immunoglobulins and other polypeptides of pig mesenteric node lymphocytes.猪肠系膜淋巴结淋巴细胞的质膜相关免疫球蛋白和其他多肽。
Biochem J. 1975 Jun;148(3):417-23. doi: 10.1042/bj1480417.
7
Common antigenic structures of HL-A antigens. VI. Common antigenic determinants located on the 33,000 Dalton alloantigenic fragment portion of papain-solubilized HL-A molecules.HL-A抗原的共同抗原结构。VI. 位于木瓜蛋白酶可溶解的HL-A分子的33,000道尔顿同种异体抗原片段部分上的共同抗原决定簇。
Immunology. 1975 Dec;29(6):1119-32.

本文引用的文献

1
THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY.高比放射性碘-131标记人生长激素的制备
Biochem J. 1963 Oct;89(1):114-23. doi: 10.1042/bj0890114.
2
HL-A antigens from hematopoietic cell lines: molecular size and electrophoretic mobility.造血细胞系的HL-A抗原：分子大小和电泳迁移率。
J Immunol. 1971 Aug;107(2):402-8.
3
An efficient method for isolation of HL-A antigens from hematopoietic cell lines.一种从造血细胞系中分离HL-A抗原的有效方法。
J Immunol. 1971 Aug;107(2):394-401.
4
Human transplantation antigens: isolation and radioimmunoassay.人类移植抗原：分离与放射免疫测定
Proc Soc Exp Biol Med. 1971 Mar;136(3):899-902. doi: 10.3181/00379727-136-35390.
5
Papain-solubilized HL-A antigens from cultured human lymphocytes contain two peptide fragments.从培养的人淋巴细胞中用木瓜蛋白酶溶解的HL-A抗原含有两个肽片段。
Proc Natl Acad Sci U S A. 1973 May;70(5):1603-7. doi: 10.1073/pnas.70.5.1603.
6
Ultracentrifuge studies on the effects of thiocyanate ion on antigen--antibody systems.关于硫氰酸根离子对抗抗原-抗体系统影响的超速离心研究。
Immunochemistry. 1969 Jan;6(1):77-83. doi: 10.1016/0019-2791(69)90180-3.
7
Characterization of soluble substances in plasma carrying HL-A alloantigenic activity and HL-A common antigenic activity.携带HL - A同种抗原活性和HL - A共同抗原活性的血浆中可溶性物质的特性分析。
Transplantation. 1973 Mar;15(3):312-9. doi: 10.1097/00007890-197303000-00008.
8
Determination of HL-A zygosity by radioimmunoassay.
Transplantation. 1972 Dec;14(6):793-6. doi: 10.1097/00007890-197212000-00021.

HL - A抗原的共同抗原结构。II. 源自木瓜蛋白酶可溶解的HL - A抗原分子的小片段

Common antigenic structures of HL-A antigens. II. Small fragments derived from papain-solubilized HL-A antigen molecules.

作者信息

Tanigaki N, Katagiri M, Nakamuro K, Kreiter V P, Pressman D

出版信息

Immunology. 1974 Jan;26(1):155-68.

PMID:4136153
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1423124/
Abstract

A distinctive fragment of the HL-A antigen molecule which retains characteristic structural features of the intact molecule has been obtained from soluble HL-A antigens by mild degradation procedures. When molecular fragments of 48,000 Daltons which are derived from cultured human lymphoid cells and carry HL-A alloantigenic activity are exposed to a pH of 2.4 in glycine buffer for 15 minutes at 0–4°, they split and a fragment of 11,000 Daltons can be isolated by gel filtration. This fragment does not carry HL-A alloantigenic activity but does carry HL-A common activity. This common activity had previously been found on papain-solubilized HL-A antigens as well as on intact lymphoid cells. It is immunogenic in rabbits and reacts with antiserum raised in rabbits against lymphoid cell membrane fractions. These small fragments appear to be characteristic, common structural components of HL-A antigen molecules of 48,000 Daltons and hence are designated `HL-A common-portion fragments'. Similar molecular fragments are found in solutions of the HL-A molecular fragments of 48,000 Daltons that have been stored in buffer at pH 7.8 at 4° for some time.

摘要

通过温和的降解程序，已从可溶性HL-A抗原中获得了HL-A抗原分子的一个独特片段，该片段保留了完整分子的特征性结构特征。当来源于培养的人淋巴细胞且具有HL-A同种异体抗原活性的48,000道尔顿分子片段，在甘氨酸缓冲液中于0-4°暴露于pH 2.4 15分钟时，它们会裂解，并且可以通过凝胶过滤分离出11,000道尔顿的片段。该片段不具有HL-A同种异体抗原活性，但具有HL-A共同活性。这种共同活性先前已在木瓜蛋白酶溶解的HL-A抗原以及完整的淋巴细胞上发现。它在兔中具有免疫原性，并与兔抗淋巴细胞膜组分血清发生反应。这些小片段似乎是48,000道尔顿HL-A抗原分子的特征性共同结构成分，因此被命名为“HL-A共同部分片段”。在4°下于pH 7.8的缓冲液中储存一段时间的48,000道尔顿HL-A分子片段的溶液中也发现了类似的分子片段。