六甲蜜胺与5-氟尿嘧啶联合治疗晚期卵巢癌的疗效评估。
Evaluation of a hexamethylmelamine and 5-fluorouracil combination in the treatment of advanced ovarian carcinoma.
作者信息
Kardinal C G, Luce J K
出版信息
Cancer Treat Rep. 1977 Dec;61(9):1691-3.
The combination of two nonalkylating agents, hexamethylmelamine (HMM) and 5-fluorouracil (5-FU), was evaluated in 14 patients with advanced ovarian carcinoma. Nine patients had been treated previously with alkylating agents. The overall response rate was 36% which is not greater than could be expected with either HMM or 5-FU alone. However, the median survival of the five responders was greater than 24 months. Treatment had to be discontinued in five of 14 patients due to excessive toxicity. Although the toxic effects were predominately gastrointestinal, unpredictable hematopoietic and neurotoxic effects were observed.
对14例晚期卵巢癌患者评估了两种非烷化剂六甲蜜胺（HMM）和5-氟尿嘧啶（5-FU）联合使用的效果。9例患者先前接受过烷化剂治疗。总体缓解率为36%，并不高于单独使用HMM或5-FU时预期的缓解率。然而，5例缓解者的中位生存期超过24个月。14例患者中有5例因毒性过大而不得不停止治疗。尽管毒性作用主要是胃肠道方面的，但也观察到了不可预测的造血和神经毒性作用。
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