[蜜蜂若虫血淋巴中葡萄糖对α-葡萄糖苷酶活性的混合“n”型抑制作用]
[Mixed "n" type inhibition of alpha-glucosidase activity by glucose in hemolymph of honeybee prenymphs].
作者信息
Bounias M
出版信息
C R Acad Hebd Seances Acad Sci D. 1977 Nov 21;285(14):1263-6.
PMID:413666
Abstract
Under in vitro inhibition of alpha-glucosidasic activity by glucose in hemolymph of Bee prenymphas, the reaction order (n) (predetermined according to the initial natural glycemia) decreases with increasing inhibitor concentration and the affinity constant between enzyme and substrate undergoes lower variations than in other cases where (n) does not change. The study of inhibited molecular forms suggests the possibility of a gradual negative-cooperativity mechanism concerning a dimeric form of the enzyme.
摘要
在蜜蜂若虫血淋巴中葡萄糖对α-葡萄糖苷酶活性的体外抑制作用下，反应级数（n）（根据初始自然血糖预先确定）随抑制剂浓度增加而降低，且酶与底物之间的亲和常数变化低于（n）不变的其他情况。对受抑制分子形式的研究表明，该酶的二聚体形式可能存在逐渐的负协同机制。
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引用本文的文献
1
Correlations between glucose-inhibition and control parameters of alpha-glucosidase kinetics in Apis mellifica haemolymph (Hymenoptera: Insecta).
Experientia. 1980 Feb 15;36(2):157-9. doi: 10.1007/BF01953704.
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