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用凝集抑制免疫测定法测定纤维蛋白（原）的抗原决定簇。

The antigenic determinant of fibrin(ogen) measured with agglutination inhibition immunoassays.

作者信息

Molla A, Donati M B, Vermylen J

出版信息

J Clin Pathol. 1974 Jun;27(6):473-9. doi: 10.1136/jcp.27.6.473.

DOI:10.1136/jcp.27.6.473
PMID:4137968
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC478158/
Abstract

Agglutination inhibition immunoassays using antifibrinogen antiserum measure an antigenic determinant of fibrinogen which is located on the fragment D parts of this molecule. This antigenic determinant of fragment D, in contrast to others, does not form an immune precipitate with antifibrinogen antiserum. Upon very extensive hydrolysis by plasmin, this antigenic determinant has a reduced affinity for its antibody.

摘要

使用抗纤维蛋白原抗血清的凝集抑制免疫测定法可检测纤维蛋白原的一种抗原决定簇，该抗原决定簇位于该分子的D片段部分。与其他抗原决定簇不同，D片段的这种抗原决定簇不会与抗纤维蛋白原抗血清形成免疫沉淀。在纤溶酶进行非常广泛的水解后，这种抗原决定簇对其抗体的亲和力会降低。

相似文献

1
The antigenic determinant of fibrin(ogen) measured with agglutination inhibition immunoassays.用凝集抑制免疫测定法测定纤维蛋白（原）的抗原决定簇。
J Clin Pathol. 1974 Jun;27(6):473-9. doi: 10.1136/jcp.27.6.473.
2
Immunobiology of fibrinogen. Emergence of neoantigenic expressions during physiologic cleavage in vitro and in vivo.纤维蛋白原的免疫生物学。体内外生理性裂解过程中新抗原表达的出现。
J Clin Invest. 1973 Feb;52(2):273-82. doi: 10.1172/JCI107183.
3
Plasmin lysis of fibrinogen and fibrin and the antigenic properties of their degradation products.纤维蛋白原和纤维蛋白的纤溶酶溶解作用及其降解产物的抗原特性。
Br J Haematol. 1972 Jan;22(1):103-10. doi: 10.1111/j.1365-2141.1972.tb08791.x.
4
Neoantigenic expressions engendered by plasmin cleavage of fibrinogen.纤维蛋白原经纤溶酶裂解产生的新抗原表达。
J Immunol. 1971 Nov;107(5):1496-500.
5
Molecular events responsible for modulation of neoantigenic expression: the cleavage-associated neoantigen of fibrinogen (blood coagulation-fibrinogen cleavage products-fibrinolysis-molecular conformation).负责调节新抗原表达的分子事件：纤维蛋白原的裂解相关新抗原（血液凝固 - 纤维蛋白原裂解产物 - 纤维蛋白溶解 - 分子构象）
Proc Natl Acad Sci U S A. 1972 Jan;69(1):208-12. doi: 10.1073/pnas.69.1.208.
6
Immunochemistry of the thrombin-altered NH2-terminal disulfide knot of human fibrinogen.
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The Tanned Red Cell Hemagglutination Inhibition Immunoassay and purified fibrinogen degradation products.鞣酸红细胞血凝抑制免疫测定法及纯化纤维蛋白原降解产物
Scand J Haematol Suppl. 1971;13:91-9. doi: 10.1111/j.1600-0609.1971.tb01992.x.
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Fibrinogen-fibrin degradation products: hemagglutination inhibition immunoassay in plasma.纤维蛋白原 - 纤维蛋白降解产物：血浆中的血凝抑制免疫测定法
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[Demonstration of antigenic determinants bound to the molecular structure in human gamma-G immunoglobulins].[人γ-G免疫球蛋白中与分子结构结合的抗原决定簇的展示]
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Degradation of fibrinogen in vitro. Demonstration of several antigenic intermediates by specific anti-D and anti-E serum.纤维蛋白原的体外降解。用特异性抗-D和抗-E血清证实几种抗原性中间产物。
Scand J Haematol. 1972;9(6):577-86. doi: 10.1111/j.1600-0609.1972.tb00989.x.

本文引用的文献

1
[Analysis, by immuno-chemical methods, of the degradation by plasmin of human fibrinogen and fibrin, at different stages].[通过免疫化学方法，对不同阶段纤溶酶降解人纤维蛋白原和纤维蛋白的分析]
Nouv Rev Fr Hematol. 1960 Nov-Dec;15:451-66.
2
[The products of degradation of human fibrinogen by plasmin. I. Separation and physicochemical properties].[纤溶酶对人纤维蛋白原的降解产物。I. 分离及理化性质]
Ann Inst Pasteur (Paris). 1961 Mar;100:377-89.
3
Quantitative estimation of split products of fibrinogen in human serum, relation to diagnosis and treatment.人血清中纤维蛋白原裂解产物的定量测定及其与诊断和治疗的关系
Blood. 1966 Jul;28(1):1-18.
4
A rapid, simple, sensitive method for measuring fibrinolytic split products in human serum.一种用于检测人血清中纤维蛋白溶解分裂产物的快速、简单、灵敏的方法。
Proc Soc Exp Biol Med. 1969 Jul;131(3):871-5. doi: 10.3181/00379727-131-33998.
5
The purification of fibrinogen degradation products by pevikon block electrophoresis.用聚乙烯醇缩甲乙醛阻滞电泳法纯化纤维蛋白原降解产物
Thromb Diath Haemorrh. 1969 Nov 15;22(2):234-9.
6
Tanned Red Cell Hemagglutination Inhibition Immunoassay for fibrinogen-fibrin-related antigen ("fibrinolytic degradation products") in human serum.人血清中纤维蛋白原 - 纤维蛋白相关抗原（“纤维蛋白溶解降解产物”）的鞣酸红细胞血凝抑制免疫测定法
Scand J Haematol Suppl. 1971;13:83-5.
7
Detection of fibrin(ogen) degradation products by a latex clumping method.
Scand J Haematol Suppl. 1971;13:115-9. doi: 10.1111/j.1600-0609.1971.tb01996.x.
8
Comparison of the Tanned Red Cell Hemagglutination Inhibition Immuno-assay and radial immunodiffusion for the quantitation of fibrinogen-related antigen in urine concentrates.鞣酸红细胞血凝抑制免疫测定法与放射免疫扩散法在浓缩尿中纤维蛋白原相关抗原定量检测中的比较
Scand J Haematol Suppl. 1971;13:225-8. doi: 10.1111/j.1600-0609.1971.tb02012.x.
9
Characterisation of large fragments rich in disulphide bridges from CNBr-treated products of exhaustive proteolysis of fibrinogen by plasmin.
Biochim Biophys Acta. 1973 Feb 21;295(2):536-42. doi: 10.1016/0005-2795(73)90050-0.
10
Plasmin digestion of stabilized and non-stabilized fibrin illustrated by immunoelectrophoresis and haemagglutination inhibition immuno assays.通过免疫电泳和血凝抑制免疫测定法展示的纤溶酶对稳定和非稳定纤维蛋白的消化作用。
Scand J Haematol. 1971;8(6):461-9. doi: 10.1111/j.1600-0609.1971.tb00899.x.