用凝集抑制免疫测定法测定纤维蛋白（原）的抗原决定簇。
The antigenic determinant of fibrin(ogen) measured with agglutination inhibition immunoassays.
作者信息
Molla A, Donati M B, Vermylen J
出版信息
J Clin Pathol. 1974 Jun;27(6):473-9. doi: 10.1136/jcp.27.6.473.
Abstract
Agglutination inhibition immunoassays using antifibrinogen antiserum measure an antigenic determinant of fibrinogen which is located on the fragment D parts of this molecule. This antigenic determinant of fragment D, in contrast to others, does not form an immune precipitate with antifibrinogen antiserum. Upon very extensive hydrolysis by plasmin, this antigenic determinant has a reduced affinity for its antibody.
摘要
使用抗纤维蛋白原抗血清的凝集抑制免疫测定法可检测纤维蛋白原的一种抗原决定簇，该抗原决定簇位于该分子的D片段部分。与其他抗原决定簇不同，D片段的这种抗原决定簇不会与抗纤维蛋白原抗血清形成免疫沉淀。在纤溶酶进行非常广泛的水解后，这种抗原决定簇对其抗体的亲和力会降低。
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本文引用的文献
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[Analysis, by immuno-chemical methods, of the degradation by plasmin of human fibrinogen and fibrin, at different stages].[通过免疫化学方法，对不同阶段纤溶酶降解人纤维蛋白原和纤维蛋白的分析]
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Comparison of the Tanned Red Cell Hemagglutination Inhibition Immuno-assay and radial immunodiffusion for the quantitation of fibrinogen-related antigen in urine concentrates.鞣酸红细胞血凝抑制免疫测定法与放射免疫扩散法在浓缩尿中纤维蛋白原相关抗原定量检测中的比较
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Scand J Haematol. 1971;8(6):461-9. doi: 10.1111/j.1600-0609.1971.tb00899.x.
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