Golinger R C
Surg Gynecol Obstet. 1978 Feb;146(2):273-85.
There is some reason to believe that common benign diseases of the breast are in great part caused by abnormalities of the hormonal milieu in which the breasts exist. Relative hyperestrinism by itself may cause mammary dysplasia, but it is likely that etiologic contributions are required from genetic factors within the cells of the mammary gland, from abnormalities of pituitary mammotropic hormone activity and from surplus or deficit of other circulating nongonadal factors.
有理由相信，乳腺常见的良性疾病在很大程度上是由乳腺所处的激素环境异常所致。单纯的相对雌激素过多本身可能会导致乳腺发育异常，但病因可能还需要乳腺细胞内的遗传因素、垂体促乳激素活性异常以及其他循环非性腺因素的过剩或不足等方面的作用。
