[Antibodies in rhesus-monkeys after experimental infection with African lung-worms (Paragonimus uterobilateralis and P. africanus) (author's transl)].

The following publication gives a report about serological studies on experimentally infected Macaca mulatta with Paragonimus uterobilateralis and P. africanus supplied by parasitological findings and chest X-ray experiments from other authors. It was shown that at first in the chronological sequence serological changes were noticed in the animals followed by X-ray changes of the lungs. Somewhat later the monkeys started with the excretion of worm-eggs. Egg production did not take place in all monkeys and was also very irregular from monkey to monkey. The passive haemagglutination and complement fixation test were suitable serological methods to indicate a Paragonimus infection in monkeys. It was shown that in older infections the complement fixation test is not as suitable as the passive haemagglutination since the complement fixing antibodies loose most of their activity within six to eight months. Antigenic relationship between the two African Paragonismus species could be demonstrated by cross-reactions with the passive haemagglutination, complement fixation and double gel diffusion test. Nevertheless by disc-electrophoretic experiment it could be proved that there were two taxonomically different Paragonimus-species in Africa.