依酚氯铵对猫骨骼肌的促进作用机制。

The effects of edrophonium have been observed in the transversely cut tenuissimus muscle of the cat.2. Concentrations of edrophonium 10(-7)M to 10(-5)M increased the amplitude of the end-plate potential (e.p.p.) but produced no greater increase in time course than previously observed in curarized muscle.3. When the e.p.p. and gross nerve action potential were recorded simultaneously, antidromic discharges were observed in the motor nerve concomitantly with repetitive e.p.ps in the presence of edrophonium.4. Edrophonium produced no effect on the input resistance or equilibrium potential of the end-plate.5. The fractional release of transmitter was significantly increased by edrophonium but there was no increase in the quantal release of transmitter in the transversely cut muscle preparation.6. In curarized muscle edrophonium also increased the quantal release, the size of the available store of transmitter and the rate of refilling of the available store.7. It is concluded that edrophonium facilitates transmission to skeletal muscle by inducing a repetitive antidromic discharge in the nerve, following orthodromic stimulation. The antidromic discharge propagates by axon reflex to other nerve terminals of the same motor unit producing repetitive e.p.ps. It is also suggested that edrophonium antagonizes tubocurarine by acting as a partial agonist at the motor nerve terminal.

已在猫的横向切断的薄肌中观察到依酚氯铵的作用。
浓度为10⁻⁷M至10⁻⁵M的依酚氯铵增加了终板电位（e.p.p.）的幅度，但在时间进程上的增加并不比先前在箭毒化肌肉中观察到的更大。
当同时记录e.p.p.和总的神经动作电位时，在依酚氯铵存在的情况下，运动神经中观察到逆向放电与重复性e.p.p.s同时出现。
依酚氯铵对终板的输入电阻或平衡电位没有影响。
依酚氯铵显著增加了递质的分数释放，但在横向切断的肌肉标本中递质的量子释放没有增加。
在箭毒化肌肉中，依酚氯铵也增加了量子释放、递质的可用储存量的大小以及可用储存量的再填充速率。
得出的结论是，依酚氯铵通过在顺向刺激后在神经中诱导重复性逆向放电来促进向骨骼肌的传递。逆向放电通过轴突反射传播到同一运动单位的其他神经末梢，产生重复性e.p.p.s。还提出依酚氯铵通过在运动神经末梢作为部分激动剂起作用来拮抗筒箭毒碱。

The mechanism of the facilitatory action of edrophonium in cat skeletal muscle.