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Chronic administration of chlorcyclizine and meclizine to rats: accumulation of a metabolite formed by piperazine ring cleavage.

作者信息

Gaertner H J, Breyer U, Liomin G

出版信息

J Pharmacol Exp Ther. 1973 May;185(2):195-201.

PMID:4145042
Abstract
摘要

相似文献

1
Chronic administration of chlorcyclizine and meclizine to rats: accumulation of a metabolite formed by piperazine ring cleavage.对大鼠长期施用氯环利嗪和美克洛嗪:哌嗪环裂解形成的一种代谢物的蓄积。
J Pharmacol Exp Ther. 1973 May;185(2):195-201.
2
Tissue accumulation of metabolites during chronic administration of piperazine-substituted phenothiazine drugs.
Adv Biochem Psychopharmacol. 1974;9(0):167-73.
3
Experimental alteration of the metabolism of chlorcyclizine and the incidence of cleft palate in rats.氯环利嗪代谢的实验性改变与大鼠腭裂发生率
J Pharmacol Exp Ther. 1967 Mar;155(3):494-505.
4
In vivo piperazine ring degradation in neuroleptic and antihistaminic drugs.
Arzneimittelforschung. 1972 Jun;22(6):1084-5.
5
N-oxide formation: a new route for inactivation of the antihistaminic chlorcyclizine.N-氧化物的形成:抗组胺药氯环利嗪失活的一条新途径。
J Pharmacol Exp Ther. 1967 Feb;155(2):337-44.
6
Effects of thalidomide and chlorcyclizine on the biosynthesis of nucleic acids and proteins in fetal and maternal tissues of the rat.沙利度胺和氯环利嗪对大鼠胎儿及母体组织中核酸和蛋白质生物合成的影响。
J Pharmacol Exp Ther. 1970 Jan;171(1):109-17.
7
Studies on an unusual N-dealkylation reaction. I. In vivo and in vitro N-dealkylation of N-t-butylnorchlorcyclizine to norchlorcyclizine by the rat.关于一种异常的N-脱烷基反应的研究。I. 大鼠体内和体外将N-叔丁基去氯环嗪脱烷基化为去氯环嗪的反应
J Pharmacol Exp Ther. 1972 Sep;182(3):507-14.
8
A sensitive assay for the hepatic N-demethylation of chlorcyclizine in vitro.一种体外测定氯环利嗪肝脏N-去甲基化的灵敏方法。
J Pharmacol Exp Ther. 1972 Aug;182(2):312-9.
9
Certain aspects of drug binding to nonplasma proteins as illustrated by studies with cyclizine, chlorcyclizine, and polymyxin B.以赛克利嗪、氯环利嗪和多粘菌素B的研究为例说明药物与非血浆蛋白结合的某些方面。
Ann N Y Acad Sci. 1973 Nov 26;226:131-47. doi: 10.1111/j.1749-6632.1973.tb20476.x.
10
Adriamycin and daunorubicin disposition in the rabbit.阿霉素和柔红霉素在兔体内的处置情况。
J Pharmacol Exp Ther. 1974 Nov;191(2):331-40.

引用本文的文献

1
Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.用于治疗丙型肝炎病毒感染的新型氯环利嗪衍生物的发现、优化及特性研究
J Med Chem. 2016 Feb 11;59(3):841-53. doi: 10.1021/acs.jmedchem.5b00752. Epub 2016 Feb 1.
2
Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection.抗组胺药氯环利嗪及相关化合物用于治疗丙型肝炎病毒感染的用途拓展。
Sci Transl Med. 2015 Apr 8;7(282):282ra49. doi: 10.1126/scitranslmed.3010286.