Sheng Jian-Xiang, Liu Yan-Jun, Yu Jing, Wang Ran, Chen Ru-Yi, Shi Jin-Jin, Yang Guan-Jun, Chen Jiong
State Key Laboratory for Quality and Safety of Agro-Products, School of Marine Sciences, Ningbo University, Ningbo, Zhejiang, 315211, China.
J Pharm Anal. 2025 Dec;15(12):101292. doi: 10.1016/j.jpha.2025.101292. Epub 2025 Apr 2.
Glutaminase 1 (GLS1) is a crucial enzyme that serves as the initial rate-limiting factor in glutaminolysis, a metabolic process that releases various factors that influence biological processes such as development, differentiation, and immune responses. Several studies have systematically investigated the crucial role of GLS1 in cancer. However, there is a lack of a comprehensive understanding of the relationship between GLS1 and inflammation. In this review, we present a detailed examination of GLS1, and discuss its structure, function, and role in inflammatory pathways. Here, we summarize the evidence supporting GLS1's involvement in several inflammatory diseases and explore the potential therapeutic applications of GLS1 inhibitors. We found that GLS1 plays a crucial regulatory role in inflammation by mediating glutaminolysis. Targeting GLS1, such as through the use of GLS1 inhibitors, can effectively alleviate inflammation induced by GLS1. Furthermore, we highlight the challenges and opportunities associated with investigating GLS1 function and developing targeted inhibitors, and propose practical solutions that offer valuable insights for the functional exploration and discovery of potential therapeutics aimed at treating inflammatory diseases.
谷氨酰胺酶1（GLS1）是一种关键酶，它是谷氨酰胺分解代谢过程中的初始限速因子，谷氨酰胺分解代谢是一种释放多种影响发育、分化和免疫反应等生物学过程的因子的代谢过程。多项研究系统地探讨了GLS1在癌症中的关键作用。然而，目前对GLS1与炎症之间的关系缺乏全面的了解。在这篇综述中，我们对GLS1进行了详细的研究，并讨论了其结构、功能以及在炎症途径中的作用。在此，我们总结了支持GLS1参与多种炎症性疾病的证据，并探讨了GLS1抑制剂的潜在治疗应用。我们发现GLS1通过介导谷氨酰胺分解代谢在炎症中发挥关键的调节作用。靶向GLS1，例如使用GLS1抑制剂，可以有效减轻GLS1诱导的炎症。此外，我们强调了研究GLS1功能和开发靶向抑制剂所面临的挑战与机遇，并提出了切实可行的解决方案，这些方案为旨在治疗炎症性疾病的潜在治疗方法的功能探索和发现提供了有价值的见解。
