Libshitz H I, Montague E D, Paulus D D
AJR Am J Roentgenol. 1978 Feb;130(2):345-7. doi: 10.2214/ajr.130.2.345.
Skin thickening of the breasts of 22 women undergoing excision biopsy of a breast cancer and subsequent radiation therapy to 5,000 rad is considered. The skin thickness of the treated breast returned to normal in 17 of 22 patients studied. Of the 17, nearly 60% returned to normal in 2 years, over 80% in 3 years, and the rest by 4 years. The period of follow-up was less than 4 years in the five patients with residual skin thickening. The alterations in skin thickness are consistent with the histopathologic changes seen in radiation dermatitis.
对22名接受乳腺癌切除活检并随后接受5000拉德放射治疗的女性乳房皮肤增厚情况进行了研究。在研究的22名患者中，17名患者接受治疗的乳房皮肤厚度恢复正常。在这17名患者中，近60%在2年内恢复正常，80%以上在3年内恢复正常，其余在4年内恢复正常。5名皮肤增厚仍有残留的患者随访时间不到4年。皮肤厚度的改变与放射性皮炎中所见的组织病理学变化一致。
