几种β-肾上腺素能受体阻断药物对妊娠绵羊和胎儿的作用。

Action of several -adrenoceptor blocking drugs in the pregnant sheep and foetus.

作者信息

Truelove J F, van Petten G R, Willes R F

出版信息

Br J Pharmacol. 1973 Jan;47(1):161-71. doi: 10.1111/j.1476-5381.1973.tb08170.x.

DOI:10.1111/j.1476-5381.1973.tb08170.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1776527/

Abstract

The effect of several beta-adrenoceptor blocking drugs on the pregnant ewe and foetus were studied. Bunolol, butidrine, oxprenolol, propranolol and USVP65-24 all crossed the ovine placenta and produced a beta-adrenoceptor blockade in the ovine foetus. AH3474, AY21011 and sotalol did not cross the ovine placenta as assessed by the absence of a beta-blockade in the foetus when these compounds were administered to the pregnant ewe.2. Of the beta-blocking compounds tested, only propranolol and oxprenolol produced a prolonged blockade in the foetus. The beta-blockade with propranolol was of 3 h duration in the ewe and 10 h duration in the foetus. Oxprenolol produced a beta-blockade of 3 h duration in the ewe and 8 h in the foetus.3. The beta-blocking drugs which did cross the ovine placenta were more soluble in organic solvents (ether, chloroform, corn oil and olive oil) than those which did not cross the ovine placenta.

摘要

研究了几种β-肾上腺素能受体阻断药物对妊娠母羊和胎儿的影响。布诺洛尔、布替林、氧烯洛尔、普萘洛尔和USVP65 - 24均能穿过绵羊胎盘，并在绵羊胎儿体内产生β-肾上腺素能受体阻断作用。当给妊娠母羊施用AH3474、AY21011和索他洛尔时，由于胎儿体内未出现β-阻断作用，表明它们未穿过绵羊胎盘。
在测试的β-阻断化合物中，只有普萘洛尔和氧烯洛尔在胎儿体内产生了持久的阻断作用。普萘洛尔对母羊的β-阻断作用持续3小时，对胎儿持续10小时。氧烯洛尔对母羊的β-阻断作用持续3小时，对胎儿持续8小时。
能穿过绵羊胎盘的β-阻断药物比不能穿过绵羊胎盘的药物在有机溶剂（乙醚、氯仿、玉米油和橄榄油）中的溶解度更高。