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抗淋巴细胞抗体对不同品系小鼠体液免疫反应的影响。3. 对3型肺炎球菌多糖的反应。

The effect of antilymphocytic antibody on the humoral immune response in different strains of mice. 3. The response to type 3 pneumococcus polysaccharide.

作者信息

Ghaffar A, James K

出版信息

Immunology. 1973 Jun;24(6):1075-85.

PMID:4146227
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1422922/
Abstract

The effect of a single batch of horse anti-mouse thymocyte globulin on the immune response to type III polysaccharide antigen has been investigated in 2–3-month-old male A/HeJ, CB1, BALB/c, DBA/1, CBA and CH mice. In almost all cases the intraperitoneal administration of 5 mg of this material on days –4 and –2 significantly suppressed the immune response to 0.1, 1.0 and 5.0 μg of antigen injected i.v. on day 0. Further studies undertaken in BALB/c mice indicated that effective suppression of the immune response to type III polysaccharide antigen could also be achieved by injecting 5 mg of this product (i.p.) some 15–30 minutes prior to antigenic challenge. Preliminary cell reconstitution studies in antilymphocytic antibody-treated CBA mice indicate that the ability to respond to type III polysaccharide can be partially restored by the injection of syngeneic thymocytes, bone marrow cells or spleen cells.

摘要

已在2至3月龄的雄性A/HeJ、CB1、BALB/c、DBA/1、CBA和CH小鼠中研究了一批马抗小鼠胸腺细胞球蛋白对III型多糖抗原免疫反应的影响。几乎在所有情况下，于第-4天和-2天腹腔注射5毫克该物质，可显著抑制于第0天静脉注射0.1、1.0和5.0微克抗原后的免疫反应。在BALB/c小鼠中进行的进一步研究表明，在抗原攻击前约15至30分钟腹腔注射5毫克该产品，也可有效抑制对III型多糖抗原的免疫反应。在抗淋巴细胞抗体处理的CBA小鼠中进行的初步细胞重建研究表明，注射同基因胸腺细胞、骨髓细胞或脾细胞可部分恢复对III型多糖的反应能力。

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本文引用的文献

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Lymphocyte activation. II. discriminating stimulation of lymphocyte subpopulations by phytomitogens and heterologous antilymphocyte sera.淋巴细胞激活。II. 植物有丝分裂原和异种抗淋巴细胞血清对淋巴细胞亚群的鉴别性刺激
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Requirement for lymphocyte-macrophage interaction in the response of mouse spleen cultures to pneumococcal polysaccharide.小鼠脾细胞培养物对肺炎球菌多糖反应中淋巴细胞 - 巨噬细胞相互作用的需求
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Strain differences in the antibody plaque-forming cell responses of inbred mice to pneumococcal polysaccharide.近交系小鼠对肺炎球菌多糖的抗体空斑形成细胞反应中的品系差异。
Cell Immunol. 1971 Feb;2(1):73-81. doi: 10.1016/0008-8749(71)90026-8.
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The effect of antilymphocytic antibody on the primary immune response of mice to sheep erythrocytes, bovine serum albumin, and type 3 pneumococcus polysaccharide.抗淋巴细胞抗体对小鼠针对绵羊红细胞、牛血清白蛋白和3型肺炎球菌多糖的初次免疫反应的影响。
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Immunology. 1970 Dec;19(6):945-57.

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