Ghaffar A, James K
Immunology. 1973 Jun;24(6):1075-85.
The effect of a single batch of horse anti-mouse thymocyte globulin on the immune response to type III polysaccharide antigen has been investigated in 2–3-month-old male A/HeJ, CB1, BALB/c, DBA/1, CBA and CH mice. In almost all cases the intraperitoneal administration of 5 mg of this material on days –4 and –2 significantly suppressed the immune response to 0.1, 1.0 and 5.0 μg of antigen injected i.v. on day 0. Further studies undertaken in BALB/c mice indicated that effective suppression of the immune response to type III polysaccharide antigen could also be achieved by injecting 5 mg of this product (i.p.) some 15–30 minutes prior to antigenic challenge. Preliminary cell reconstitution studies in antilymphocytic antibody-treated CBA mice indicate that the ability to respond to type III polysaccharide can be partially restored by the injection of syngeneic thymocytes, bone marrow cells or spleen cells.
已在2至3月龄的雄性A/HeJ、CB1、BALB/c、DBA/1、CBA和CH小鼠中研究了一批马抗小鼠胸腺细胞球蛋白对III型多糖抗原免疫反应的影响。几乎在所有情况下,于第-4天和-2天腹腔注射5毫克该物质,可显著抑制于第0天静脉注射0.1、1.0和5.0微克抗原后的免疫反应。在BALB/c小鼠中进行的进一步研究表明,在抗原攻击前约15至30分钟腹腔注射5毫克该产品,也可有效抑制对III型多糖抗原的免疫反应。在抗淋巴细胞抗体处理的CBA小鼠中进行的初步细胞重建研究表明,注射同基因胸腺细胞、骨髓细胞或脾细胞可部分恢复对III型多糖的反应能力。