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抗淋巴细胞抗体对不同品系小鼠体液免疫反应的影响。II. 对绵羊红细胞的反应。

The effect of antilymphocytic antibody on the humoral immune response in different strains of mice. II. The response to sheep erythrocytes.

作者信息

Ghaffar A, James K

出版信息

Immunology. 1973 Mar;24(3):455-65.

PMID:4574575
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1422968/
Abstract

The effect of an horse anti-mouse thymocyte globulin (ALG) preparation on the primary and secondary immune responses to sheep erythrocytes (RBC) was studied in 2–3-month-old male A/HeJ, C57B1, BALB/c, DBA/1, CBA and C3H mice. A wide variation in the primary and secondary responses of the individual strains was noticed but in all cases these were significantly suppressed by ALG pretreatment. The capacity of the ALG to suppress the primary immune response was not overcome by increasing the antigen dose from 3 × 10 to 3 × 10 sheep RBC.

摘要

研究了马抗小鼠胸腺细胞球蛋白（ALG）制剂对2至3月龄雄性A/HeJ、C57B1、BALB/c、DBA/1、CBA和C3H小鼠对绵羊红细胞（RBC）的初次和二次免疫反应的影响。观察到各个品系的初次和二次反应存在很大差异，但在所有情况下，ALG预处理均能显著抑制这些反应。将抗原剂量从3×10增加到3×10绵羊红细胞，并未克服ALG抑制初次免疫反应的能力。

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本文引用的文献

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DISTRIBUTION OF ANTIBODY PLAQUE FORMING CELLS IN VARIOUS TISSUES OF SEVERAL STRAINS OF MICE INJECTED WITH SHEEP ERYTHROCYTES.注射绵羊红细胞后几种品系小鼠不同组织中抗体形成细胞的分布情况。
Proc Soc Exp Biol Med. 1964 Nov;117:526-30. doi: 10.3181/00379727-117-29628.
2
The effect of immunologically induced lymphopenia on antibody formation.免疫诱导淋巴细胞减少对抗体形成的影响。
J Immunol. 1969 Jan;102(1):187-93.
3
Genetic control of the antibody response: relationship between immune response and histocompatibility (H-2) type.抗体反应的遗传控制：免疫反应与组织相容性（H-2）类型之间的关系。
Science. 1969 Mar 14;163(3872):1207-8. doi: 10.1126/science.163.3872.1207.
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J Immunol. 1968 Dec;101(6):1283-90.
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