γ-羟基丁酸对氯丙嗪诱导的高香草酸增加的抑制作用。
Inhibition by gamma-hydroxybutyrate of chlorpromazine-induced increase in homovanillic acid.
作者信息
Roth R H
出版信息
Br J Pharmacol. 1973 Feb;47(2):408-14. doi: 10.1111/j.1476-5381.1973.tb08338.x.
Abstract
- gamma-Hydroxybutyrate and its lactone precursor, gamma-butyrolactone, when administered in anaesthetic doses block the increase in the cerebral concentration of homovanillic acid normally observed after administration of chlorpromazine or haloperidol.2. Other hypnotics such as glutethimide, urethane, chloralose, chloral hydrate and thiopentone do not have this ability even when administered in anaesthetic doses.3. The ability of gamma-hydroxybutyrate to block the neuroleptic-induced increase in cerebral homovanillic acid is not due to a reduction in body temperature since a similar effect is observed in rats treated under conditions (32 degrees C) in which body temperature remains normal.4. Possible mechanisms for this action of gamma-hydroxybutyrate are discussed.
摘要
γ-羟基丁酸及其内酯前体γ-丁内酯，在给予麻醉剂量时，可阻断氯丙嗪或氟哌啶醇给药后通常观察到的脑内高香草酸浓度的升高。
其他催眠药，如格鲁米特、氨基甲酸乙酯、氯醛糖、水合氯醛和硫喷妥钠，即使给予麻醉剂量也没有这种能力。
γ-羟基丁酸阻断抗精神病药物引起的脑内高香草酸升高的能力并非由于体温降低，因为在体温保持正常的条件下（32摄氏度）处理的大鼠中也观察到了类似的效果。
讨论了γ-羟基丁酸这种作用的可能机制。
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