羟丁酸钠对大脑中多巴胺代谢的影响。
The effect of sodium -hydroxybutyrate on the metabolism of dopamine in the brain.
作者信息
Hutchins D A, Rayevsky K S, Sharman D F
出版信息
Br J Pharmacol. 1972 Nov;46(3):409-15. doi: 10.1111/j.1476-5381.1972.tb08138.x.
Abstract
- Sodium gamma hydroxybutyrate (GHB-Na), when given to rats and mice, caused a sleep-like state and a fall in body temperature of about 10 degrees C.2. GHB-Na produced a dose-dependent increase in the concentration of dopamine (DA) in the brains of mice kept at an environmental temperature of 18-20 degrees C or 30-32 degrees C.3. The concentrations of 3,4-dihydroxyphenylacetic acid (DOPAC) and 4-hydroxy-3-methoxyphenylacetic acid (HVA), the metabolites of DA, were increased in the striatal tissues of rats and mice, after the administration of GHB-Na. However there was a delay of 60 min before the concentration of HVA increased whereas there appeared to be little delay before the concentration of DOPAC increased.4. When GHB-Na was administered to reserpine-treated animals, no increase occurred in the concentration of dopamine in the brains of mice or rats, or of DOPAC in the rat brain.5. Reserpine did not prevent the induction of the sleep-like state by GHB-Na.6. The results presented suggest that the effect of GHB-Na in increasing the concentration of DA requires unimpaired storage mechanisms for the amine.
摘要
给大鼠和小鼠注射γ-羟基丁酸钠（GHB-Na）后，会使其进入类似睡眠的状态，体温下降约10摄氏度。
在环境温度为18 - 20摄氏度或30 - 32摄氏度的条件下，GHB-Na会使小鼠大脑中的多巴胺（DA）浓度呈剂量依赖性增加。
给大鼠和小鼠注射GHB-Na后，其纹状体组织中DA的代谢产物3,4-二羟基苯乙酸（DOPAC）和4-羟基-3-甲氧基苯乙酸（HVA）的浓度会升高。然而，HVA浓度升高前有60分钟的延迟，而DOPAC浓度升高前似乎几乎没有延迟。
给利血平处理过的动物注射GHB-Na后，小鼠或大鼠大脑中的多巴胺浓度以及大鼠大脑中的DOPAC浓度均未升高。
利血平不能阻止GHB-Na诱导类似睡眠的状态。
所呈现的结果表明，GHB-Na增加DA浓度的作用需要胺类物质的储存机制完好无损。
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