非人灵长类猕猴（Macaca mulatta）中丙酮酸脱氢酶的发育。

The development of pyruvate dehydrogenase in the subhuman primate Macaca mulatta.

作者信息

Robinson B H, Sherwood W G, Oei J

出版信息

Biol Neonate. 1977;32(3-4):154-7. doi: 10.1159/000241010.

Abstract

The development of total pyruvate dehydrogenase activity in the subhuman primate, Macaca mulatta, was investigated in brain, liver, kidney cortex, and skeletal and cardiac muscle. Newborn primates delivered prematurely at 135 days of gestation had only 32% of this enzyme activity present in the brain compared to the full-term animal. Full-term animals were similar to adults. All tissues showed high activities of enzyme at 1 year of age compared either with neonates or adults. Kidney cortex showed an increase in activity from 807 +/- 74 mumol/g/min in prematurely delivered neonates to a maximum of 3,769 +/- 275 mumol/g/min in 1-year-old animals. The results are discussed in relation to the developing energy requirements of the tissues concerned.

摘要

对猕猴（Macaca mulatta）这一非人灵长类动物的脑、肝、肾皮质、骨骼肌和心肌中总丙酮酸脱氢酶活性的发育情况进行了研究。妊娠135天早产的新生灵长类动物，其脑中该酶的活性仅为足月动物的32%。足月动物与成年动物相似。与新生儿或成年动物相比，所有组织在1岁时酶活性都很高。肾皮质的活性从早产新生儿的807±74μmol/g/分钟增加到1岁动物的最高值3769±275μmol/g/分钟。结合相关组织不断变化的能量需求对这些结果进行了讨论。