Skolnick P, Daly J W
Science. 1974 Apr 12;184(4133):175-7. doi: 10.1126/science.184.4133.175.
Responses of norepiniephrine sensitive adeniosinie 3',5'-monophosphate (cyclic AMP)-generating systems in combined midbrain-striatal slices of four rat strains correlate positively with spontaneous behavioral activity and negatively with levels of midbrain and striatal tyrosine hydroxylase. Responses of cerebral cortical norepinephrine-sensitive cyclic AMP systems correlate negatively with spontaneous behavioral activity antd positively with midbrain and striatal tyrosine hydroxylase. Such correlations were not found with responses of the cyclic AMP- generatinlg systems to isoproterenol, adenosine. veratridine or of an adenosne and norepinephrine combination.
四种大鼠品系的中脑-纹状体联合切片中，去甲肾上腺素敏感的3',5'-单磷酸腺苷（环磷酸腺苷）生成系统的反应与自发行为活动呈正相关，与中脑和纹状体酪氨酸羟化酶水平呈负相关。大脑皮质去甲肾上腺素敏感的环磷酸腺苷系统的反应与自发行为活动呈负相关，与中脑和纹状体酪氨酸羟化酶呈正相关。环磷酸腺苷生成系统对异丙肾上腺素、腺苷、藜芦碱或腺苷与去甲肾上腺素组合的反应未发现此类相关性。
