对豚鼠输精管纵肌的传递：胍乙啶预处理的影响。
Transmission to the longitudinal muscle of the guinea-pig vas deferens: The effect of pretreatment with guanethidine.
作者信息
Furness J B
出版信息
Br J Pharmacol. 1974 Jan;50(1):63-8. doi: 10.1111/j.1476-5381.1974.tb09593.x.
Abstract
1 Tissue was taken from guinea-pigs that had been injected with guanethidine (100 mg/kg, i.p.) 24 h before they were killed, and from paired control animals.2 Pretreatment with guanethidine caused a significant, substantial, and sometimes complete reduction of the nerve-mediated contractions of the vas deferens. There were no significant changes in the responses of the ileum to stimulation of cholinergic nerves or of the distal colon to stimulation of intrinsic (non-adrenergic) inhibitory nerves. Responses of the vas deferens and ileum to acetylcholine were unchanged, but contractions of the vas deferens elicited by exogenous noradrenaline were enhanced.3 The nerve-mediated contractions of the vas deferens were restored by exposing it to (+)-amphetamine followed by noradrenaline in vitro.4 It is concluded that noradrenaline is the transmitter released from motor nerves to the longitudinal muscle of the guinea-pig vas deferens. Possible explanations for the ineffectiveness of receptor blocking agents in antagonizing transmission are discussed.
摘要
组织取自处死前24小时腹腔注射胍乙啶（100毫克/千克）的豚鼠，以及配对的对照动物。
胍乙啶预处理导致输精管神经介导的收缩显著、大幅且有时完全减弱。回肠对胆碱能神经刺激的反应以及远端结肠对内在（非肾上腺素能）抑制性神经刺激的反应无显著变化。输精管和回肠对乙酰胆碱的反应未改变，但外源性去甲肾上腺素引起的输精管收缩增强。
通过在体外将输精管暴露于（+）-苯丙胺后再给予去甲肾上腺素，神经介导的输精管收缩得以恢复。
得出的结论是，去甲肾上腺素是从豚鼠输精管纵行肌运动神经释放的递质。讨论了受体阻断剂在拮抗传递方面无效的可能解释。
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