环层小体交感神经支配的作用。
Role of the sympathetic innervation of the pacinian corpuscle.
作者信息
Schiff J D
出版信息
J Gen Physiol. 1974 May;63(5):601-8. doi: 10.1085/jgp.63.5.601.
Abstract
An investigation was made into the nature of the role played by the noradrenergic innervation of the pacinian corpuscle. Corpuscles of the cat mesentery and mesocolon were used in all experiments. Blockade of noradrenergic beta receptors by dichloroisoproterenol and interference with norepinephrine release by reserpine are each capable of reversibly blocking mechanoelectric transduction by the pacinian corpuscle. The monoamine oxidase inhibitors iproniazid and phenelzine are capable of protecting the transducer from the blocking effects of reserpine. It is concluded that the presence of norepinephrine, as maintained by sympathetic tonus, is required for the afferent nerve terminal of the pacinian corpuscle to be mechanosensitive.
摘要
对环层小体的去甲肾上腺素能神经支配所起作用的性质进行了研究。所有实验均使用猫肠系膜和结肠系膜的小体。二氯异丙肾上腺素对去甲肾上腺素能β受体的阻断以及利血平对去甲肾上腺素释放的干扰，均能可逆性地阻断环层小体的机械电转换。单胺氧化酶抑制剂异烟酰异丙肼和苯乙肼能够保护换能器免受利血平的阻断作用。得出的结论是，环层小体的传入神经末梢要具有机械敏感性，需要有由交感神经紧张性维持的去甲肾上腺素存在。
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本文引用的文献
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The action of sympathomimetic amines in animals treated with reserpine.交感神经胺在接受利血平治疗的动物体内的作用。
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Monoamine oxidase inhibitors.单胺氧化酶抑制剂
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The accumulation of [3H]noradrenaline in the adrenergic nerve fibres of reserpine-treated mice.利血平处理小鼠的肾上腺素能神经纤维中[3H]去甲肾上腺素的蓄积。
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