药物-受体相互作用机制的分子轨道研究。1. 肾上腺素能药物。异丙肾上腺素和1-（对硝基苯基）-2-异丙氨基乙醇的构象与反应活性 - Suppr | 超能文献

Molecular orbital studies on the mechanism of drug-receptor interaction. 1. Adrenergic drugs. Conformation and reactivity of isoproterenol and 1-(p-nitrophenyl)-2-isopropylaminoethanol.

作者信息

Petrongolo C, Tomasi J

出版信息

J Med Chem. 1974 May;17(5):501-7. doi: 10.1021/jm00251a006.

DOI:10.1021/jm00251a006

Abstract

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Molecular orbital studies on the mechanism of drug-receptor interaction. 1. Adrenergic drugs. Conformation and reactivity of isoproterenol and 1-(p-nitrophenyl)-2-isopropylaminoethanol.药物-受体相互作用机制的分子轨道研究。1. 肾上腺素能药物。异丙肾上腺素和1-（对硝基苯基）-2-异丙氨基乙醇的构象与反应活性

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Conformation effects on the activity of drugs. 4. Cyclic analogs of 1-(p-nitrophenyl)-2-isopropylaminoethanol. Synthesis and evaluation of the adrenergic beta-receptor blocking activity of 2-(p-nitrophenyl)-4-isopropylmorpholine.构象对药物活性的影响。4. 1-(对硝基苯基)-2-异丙氨基乙醇的环状类似物。2-(对硝基苯基)-4-异丙基吗啉的肾上腺素β受体阻断活性的合成与评价。

J Med Chem. 1973 Mar;16(3):224-7. doi: 10.1021/jm00261a012.

3

Molecular orbital studies on the mechanism of drug-receptor interaction. 2. beta-Adrenergic drugs. An approach to explain the role of the aromatic moiety.

J Med Chem. 1977 Dec;20(12):1645-53. doi: 10.1021/jm00222a021.

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Amine-induced influence on spontaneous ovarian contractility in the guinea pig and the cat.胺对豚鼠和猫卵巢自发性收缩的影响。

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Pyridine isosteres of the -adrenergic antagonists, 2-(p-nitrophenyl)-1-isopropylamino-2-ethanol and 3-(p-nitrophenoxy)-1-isopropylamino-2-propanol.

J Med Chem. 1972 Dec;15(12):1321-4. doi: 10.1021/jm00282a028.

6

alpha-(4-chloro-3-nitrophenyl)-beta-aminoethanols: potential beta-adrenergic blocking agents.α-（4-氯-3-硝基苯基）-β-氨基乙醇：潜在的β-肾上腺素能阻滞剂。

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Effect of beta-adrenergic blocking agents on the spontaneous motility of mice.β-肾上腺素能阻滞剂对小鼠自发运动的影响。

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Irreversible adrenergic -receptor antagonism by (R)-and (S)-N-(2-chloroethyl)-N-methyl-2-phenyl-2-hydroxyethylamine and related agents.（R）-和（S）-N-（2-氯乙基）-N-甲基-2-苯基-2-羟乙胺及相关药物对肾上腺素能受体的不可逆拮抗作用。

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J Pharmacol Exp Ther. 1968 Apr;160(2):308-14.

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