一种新型α和β肾上腺素能受体拮抗剂（AH5158）对完整犬的全身和冠状动脉血流动力学的影响。
The effects of a new alpha- and beta-adrenoceptor antagonist (AH5158) upon the general and coronary haemodynamics of intact dogs.
作者信息
Maxwell G M
出版信息
Br J Pharmacol. 1973 Oct;49(2):370-2. doi: 10.1111/j.1476-5381.1973.tb08387.x.
Abstract
AH5158, a salicylamide derivative, said to be a blocker of alpha- and beta-adrenoceptors, has been studied in intact anaesthetized dogs. At a dose of 2.5 mg/kg intravenously, the drug increased cardiac output and caused a late fall in mean systemic and pulmonary arterial pressure. Coronary sinus flow increased, as did cardiac oxygen extraction. External cardiac efficiency decreased. Blood glucose and non-esterified fatty acid values increased, but cardiac extraction of these did not change.
摘要
AH5158是一种水杨酰胺衍生物，据说它是α和β肾上腺素能受体阻滞剂，已在完整的麻醉犬身上进行了研究。静脉注射剂量为2.5毫克/千克时，该药物增加了心输出量，并导致平均体循环和肺动脉压后期下降。冠状窦血流量增加，心脏氧摄取量也增加。心脏外部效率降低。血糖和非酯化脂肪酸值升高，但心脏对这些物质的摄取没有变化。
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