急性和慢性吗啡处理与小鼠脑中(1-¹⁴C)-L-酪氨酸的羟基化作用
Acute and chronic morphine treatment and the hydroxylation of (1-14C)-L-tyrosine in the mouse brain.
作者信息
Marshall I, Smith C B
出版信息
Br J Pharmacol. 1974 Mar;50(3):428-30. doi: 10.1111/j.1476-5381.1974.tb09620.x.
Abstract
Tyrosine hydroxylase activity in slices of caudate nucleus was increased by morphine (100 mg/kg i.p.) administered to naive mice. During chronic treatment with morphine tolerance developed to this effect and 36 h after the final chronic morphine injection there was a decrease in enzyme activity in this area. There was no change in tyrosine hydroxylase activity in slices of diencephalon, brainstem or parietal cortex from either naive or morphine tolerant mice. There- fore, changes in tyrosine hydroxylase activity, measured in vitro, could account for the changes in dopamine synthesis, but not noradrenaline synthesis, produced by morphine in vivo.
摘要
给未用药的小鼠腹腔注射吗啡（100毫克/千克）后，尾状核切片中的酪氨酸羟化酶活性增强。在吗啡长期治疗过程中，会产生对此效应的耐受性，并且在最后一次长期吗啡注射36小时后，该区域的酶活性降低。未用药小鼠或吗啡耐受小鼠的间脑、脑干或顶叶皮质切片中的酪氨酸羟化酶活性均无变化。因此，体外测量的酪氨酸羟化酶活性变化可解释吗啡在体内引起的多巴胺合成变化，但不能解释去甲肾上腺素合成变化。
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